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Does complete deficiency of muscle α actinin 3 alter functional capacity in elderly women? A preliminary report
  1. A F San Juan,
  2. F Gomez-Gallego,
  3. S Cañete,
  4. C Santiago,
  5. M Pérez,
  6. A Lucia
  1. Universidad Europea de Madrid, Spain
  1. Correspondence to:
 Professor Lucia
 Universidad Europea de Madrid, Madrid 28670, Spain; alejandro.lucia{at}uem.es

Abstract

The sarcomeric protein α actinin 3 is localised to the Z line of fast fibres, which are responsible for generating forceful muscle contractions at high velocity. However, a substantial proportion of healthy humans are totally deficient in this protein as they are homozygous for a premature stop codon polymorphism (R577X) in the ACTN3 gene. The purpose of this preliminary study was to assess if the presence or absence of α actinin 3 influences the deleterious effects of ageing on muscle output and functional capacity.

  • ACTN3 gene
  • ageing
  • muscle
  • functional capacity
  • strength

https://doi.org/10.1136/bjsm.2005.019539

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    Footnotes

    • Competing interests: none declared

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      BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine
      British Journal of Sports Medicine 2005; 40 54-54 Published Online First: 21 Dec 2005.