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Could platelet rich plasma have effects on systemic circulating growth factors and cytokine release in orthopaedic applications?
  1. G Banfi1,
  2. M M Corsi2,
  3. P Volpi3
  1. 1IRCCS Galeazzi and University of Milan, Milan, Italy
  2. 2Patologia Clinica, University of Milan
  3. 3IRCCS Galeazzi
  1. Correspondence to:
 Mr Banfi
 Università Milano Scuola Specializzazione Biochimica Clinica, Via R Galeazzi 4, Milano 20161, Italy; giuseppebanfi{at}

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The use of platelet rich plasma (PRP) has been proposed for tendon and ligament healing. The rationale is the release of large amounts of growth factors and cytokines with regenerative, anabolic, and anti-inflammatory effects on damaged tissues.1–3

We applied PRP in tendinopathies of professional athletes. PRP was obtained using the gravitational platelet separation system GPS II (Biomet, Bridgend, Wales, UK) from 30 ml peripheral anticoagulated whole blood, and introduced by a syringe to multiple sites of injured tendon.

After obtaining informed consent, we measured a series of cytokines and growth factors in serum obtained from peripheral blood of five male subjects (age 20–35 years; four cases of patella tendinopathy and one elbow tendinosis) to evaluate the eventual, systemic effects of such local treatment. Blood was withdrawn before treatment and …

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  • Published Online First 18 August 2006