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Immunoglobulin responses to a repeated bout of downhill running
  1. A J McKune1,
  2. L L Smith1,
  3. S J Semple1,
  4. B Mokethwa2,
  5. A A Wadee2
  1. 1Tshwane University of Technology, Pretoria, South Africa
  2. 2University of the Witwatersrand, Johannesburg, South Africa
  1. Correspondence to:
 A J McKune
 Tshwane University of Technology, Sport and Physical Rehabilitation Sciences, Pretoria 0001, South Africa; mckuneaj{at}


Objective: To examine the effect of downhill running on immunoglobulin responses.

Method: Eleven untrained men performed 2 × 60 minute bouts of downhill running (−13.5% gradient), at a speed eliciting 75% of their V̇o2peak on a level grade. Two runs were spaced 14 days apart. Serum samples were collected before, after, and every hour for 12 hours and every 24 hours for six days. Serum total creatine kinase and immunoglobulin isotypes and subclasses were measured, and results were analysed using a repeated measures analysis of variance (12 hour period, 2 × 14; 24 hour intervals, 2 × 6, p⩽0.05).

Results: There was a significant interaction effect for creatine kinase (activity lower after run 2 than after run 1, 6–24 h) and exercise effect, with the serum concentrations of IgG1, IgG2, IgG4, and IgE lower, and IgM higher, after run 2.

Conclusion: Lower concentrations of IgG1, IgG2, and IgE after run 2 may reflect a dampened autoimmune inflammatory response to autoantigens and enhanced autoantigen clearance mediated by the upregulation of IgM.

  • antibody
  • autoantigens
  • immunoglobulin response
  • inflammation
  • eccentric exercise

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  • Published Online First 18 August 2006

  • Competing interests: none declared