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Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme


Objective: To investigate the association between muscle-specific creatine kinase (CKMM) gene polymorphism and the effects of endurance training on running economy.

Methods: 102 biologically unrelated male volunteers from northern China performed a 5000-m running programme, with an intensity of 95–105% ventilatory threshold. The protocol was undertaken three times per week and lasted for 18 weeks. Running economy indexes were determined by making the participants run on a treadmill before and after the protocol, and the A/G polymorphism in the 3′ untranslated region of CKMM was detected by polymerase chain reaction-restricted fragment length polymorphism (NcoI restriction enzyme).

Results: Three expected genotypes for CKMM-NcoI (AA, AG and GG) were observed in the participants. After training, all running economy indexes declined markedly. Change in steady-state consumption of oxygen, change in steady-state consumption of oxygen by mean body weight, change in steady-state consumption of oxygen by mean lean body weight and change in ventilatory volume in AG groups were larger than those in AA and GG groups.

Conclusions: The findings indicate that the CKMM gene polymorphism may contribute to individual running economy responses to endurance training.

  • CKMM, muscle-specific creatine kinase
  • PCR, polymerase chain reaction

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