Mesenchymal cells recruited to damaged tissues must circulate through the bloodstream. The absolute numbers of circulating mesenchymal stem cells (cMSCs) in two different models of acute and chronic skeletal muscle injury were determined. cMSCs were present in significantly higher numbers in both models than in healthy controls. These results support the hypothesis that MSCs are mobilised into the bloodstream after skeletal muscle tissue damage. These two models (acute and chronic) would be of value in the search for molecular mediators of mobilisation of MSCs into the circulation.
- cMSC, circulating mesenchymal stem cell
- MSC, mesenchymal stem cell
- TnI-c, cardiac isoform of troponin I
- McArdle’s disease
- flow cytomery
- mesenchymal stem cells
- muscle damage
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Published Online First 28 June 2006
Competing interests: none declared
Financial support: supported by grants from Fondo de Investigaciones Sanitarias (FIS) numbers p1040487, p1041157, p1040362, and p1052217 and Fundacíon Oncohematogía Infantil.