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Can patients with McArdle’s disease run?
  1. M Pérez1,
  2. M Moran3,
  3. C Cardona1,
  4. J L Maté-Muñoz1,
  5. J C Rubio3,
  6. A L Andreu2,
  7. M A Martin3,
  8. J Arenas3,
  9. A Lucia1
  1. 1Universidad Europea de Madrid, Madrid, Spain
  2. 2Hospital Universitari Val d’Hebron, Barcelona, Spain
  3. 3Hospital Universitario 12 de Octubre, Madrid, Spain
  1. Correspondence to:
 Alejandro Lucia
 Universidad Europea de Madrid, Physiology, Madrid 28670, Spain; alejandro.lucia{at}


Patients with McArdle’s disease commonly adopt a sedentary lifestyle. This sedentary behaviour, however, usually worsens the limited exercise capacity of these patients. Although eccentric muscle work can be associated with rhabdomyolysis, supervised eccentric training with gradually increasing loads has important advantages compared with conventional concentric work, particularly for patients with a poor cardiorespiratory system. We report the beneficial effects (particularly, increased VO2peak (from 14.6 to 30.8 ml/kg/min) and increased gross muscle efficiency (from 13.8% to 17.2%)) induced by a supervised aerobic training programme of 7 months duration including 3–4 running sessions (⩽60 min/session) per week in a 38-year-old patient. These preliminary data suggest the potential therapeutic value of this type of exercise in these patients.

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  • Funding: This work was supported by grants from FIS numbers PI040487, PI041157 and PI040362. JCR was supported by a grant from FIS CAO5/0039 Ministerio de Sanidad y Consumo, Madrid, Spain.

  • Competing interests: None declared.

  • Informed consent was obtained for publication of the patient’s details described in this report.

  • Published Online First 25 September 2006