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Resistance exercise does not affect the serum concentrations of cell adhesion molecules
  1. Anatoli Petridou1,
  2. Athanasios Chatzinikolaou2,
  3. Ioannis Fatouros2,
  4. George Mastorakos3,
  5. Asimina Mitrakou4,
  6. Helen Chandrinou5,
  7. Ioannis Papassotiriou6,
  8. Vassilis Mougios1
  1. 1Department of Physical Education and Sport Science, Aristotle University of Thessaloniki, Thessaloniki, Greece
  2. 2Department of Physical Education and Sport Science, Democritus University of Thrace, Thrace, Greece
  3. 3Endocrine Unit, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece
  4. 4Department of Internal Medicine, Henry Dunant Hospital, Athens, Greece
  5. 5Blood Transfusion Service, Henry Dunant Hospital, Athens, Greece
  6. 6Department of Clinical Biochemistry, “Aghia Sophia” Children’s Hospital, Athens, Greece
  1. Correspondence to:
 Dr Vassilis Mougios
 TEFAA, University of Thessaloniki, 541 24 Thessaloniki, Greece; mougios{at}


Background: Cell adhesion molecules are proteins expressed on the surface of a variety of cells and mediate the leucocyte response to inflammation. Some of these molecules are released to the plasma as soluble forms, whose presence indicates the degree of vascular endothelial activation or dysfunction. Increased concentrations of soluble adhesion molecules are thought to hamper the immune response and mediate the atherosclerotic inflammatory process. Studies on the effect of exercise on the concentrations of soluble adhesion molecules have almost exclusively used aerobic exercise.

Aim: To assess the effect of resistance exercise on the serum concentrations of five cell adhesion molecules during and immediately after 30 min of exercise in lean and obese participants.

Methods: Fourteen healthy young men (eight lean and six obese) performed 3 sets of 10 resistance exercises with 10–12 repetitions at 70–75% of one repetition maximum in a circuit training fashion. Venous blood samples were drawn at baseline and at the end of the first, second and third sets. The serum concentrations of vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, E-selectin, P-selectin and L-selectin were measured in a biochip array analyser.

Results: No significant changes were observed in the concentrations of these cell adhesion molecules during exercise, or between lean and obese participants.

Conclusion: Our data indicate that resistance exercise of moderate to high intensity does not affect the serum concentrations of cell adhesion molecules in healthy young lean or obese men, suggesting no considerable negative effect on immune function.

  • BMI, body mass index
  • ICAM, intercellular cell adhesion molecule
  • VCAM, vascular cell adhesion molecule

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  • Published Online First 24 November 2006

  • Competing interests: None declared.