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Effect of maximal exercise on the short-term kinetics of zinc metabolism in sedentary men
  1. Stella Lucia Volpe1,
  2. Nicola M Lowe2,
  3. Leslie R Woodhouse3,
  4. Janet C King4
  1. 1University of Pennsylvania, Philadelphia, Pennsylvania, USA
  2. 2University of Central Lancashire, Preston, UK
  3. 3USDA/ARS/WHNRC, University of California, Davis, California, USA
  4. 4Children’s Hospital Oakland Research Institute, Oakland, California, USA
  1. Correspondence to:
 Dr S L Volpe
 Division of Biobehavioral and Health Sciences, University of Pennsylvania, School of Nursing, Nursing Education Building, 420 Guardian Drive, Philadelphia, PA 19104-6096, USA;svolpe{at}


Objective: To examine the effect of acute exhaustive exercise versus rest on short-term zinc kinetics in men.

Design: Crossover design, wherein all subjects were their own control.

Setting: University setting, where subjects were free living.

Participants: 12 healthy, sedentary men, 25–35 years of age.

Interventions:70Zn was infused 10 min after exercise or at rest. Plasma zinc concentrations were measured at baseline and 2, 5, 10, 15, 30, 45, 60, 75, 90 and 120 min after exercise or rest. Haematocrit was measured before and after exercise to assess changes in plasma volume.

Main outcome measurements: Plasma zinc (primary), serum creatine kinase and serum cortisol concentrations (secondary).

Results: Plasma zinc concentrations decreased (p<0.05) after exercise, with a mean (SD) nadir of 13.9% (4.1%) observed at 70 min after exercise. There were increases in the size of the rapidly exchangeable plasma zinc pool (Qa; from 3.1 (0.2) to 3.6 (0.2) mg; p<0.05) and the liver zinc pool (Qb; from 10.2 (0.6) to 11.4 (0.8) mg; p = 0.12).

Conclusion: Exercise seems to cause a shift of plasma zinc into the interstitial fluid and liver after exercise, which may reflect the acute stress response of strenuous exercise.

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  • Published Online First 29 November 2006

  • Funding: This project was supported by National Institutes of Health Nutrition Training Grant # T32.HD07266-10.

  • Competing interests: None.

  • Each of the authors contributed to the entire process of this paper—from data collection and analyses to the final product of this manuscript.