Objective: To test the hypothesis that microwave hyperthermia treatment (MHT) increases heat shock proteins (HSPs) in the human vastus lateralis muscle.
Methods: Four untrained healthy male volunteers participated in this study. The lateral side of the thigh of one leg (heated leg) was heated with a microwave generator (2.5 GHz, 150 W) for 20 min. At 1 day after the MHT, a muscle sample was taken from the heated leg. A control sample was taken from the unheated leg on another day of the MHT. For both legs, HSP90, HSP72 and HSP27 levels were compared.
Results: The HSP90, HSP72 and HSP27 levels in heated legs were significantly higher than those in control legs (p<0.05).
Conclusions: Application of MHT can increase the levels of several HSPs in human skeletal muscle.
- HSP, heat shock protein
- MHT, microwave hyperthermia treatment
- MyHC, myosin heavy chain
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Funding: Our research was partly supported by grants from Juntendo University and a Grant-in-Aid for Scientific Research (16300212 and 12480011 to HN) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Competing interests: None declared.
Published Online First 15 January 2007
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