Objective: To test the hypothesis that microwave hyperthermia treatment (MHT) increases heat shock proteins (HSPs) in the human vastus lateralis muscle.
Methods: Four untrained healthy male volunteers participated in this study. The lateral side of the thigh of one leg (heated leg) was heated with a microwave generator (2.5 GHz, 150 W) for 20 min. At 1 day after the MHT, a muscle sample was taken from the heated leg. A control sample was taken from the unheated leg on another day of the MHT. For both legs, HSP90, HSP72 and HSP27 levels were compared.
Results: The HSP90, HSP72 and HSP27 levels in heated legs were significantly higher than those in control legs (p<0.05).
Conclusions: Application of MHT can increase the levels of several HSPs in human skeletal muscle.
- HSP, heat shock protein
- MHT, microwave hyperthermia treatment
- MyHC, myosin heavy chain
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Funding: Our research was partly supported by grants from Juntendo University and a Grant-in-Aid for Scientific Research (16300212 and 12480011 to HN) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Competing interests: None declared.
Published Online First 15 January 2007