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  1. Martin P Schwellnus
  1. University of Cape Town, South Africa

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    Marqueti RC, Parizotto NA, Chriguer RS, et al. Am J Sports Med 2006;34:1274–80


    Anabolic-androgenic steroids (AAS), despite being on the banned list, are still used by athletes to enhance performance; however, AAS have been shown to have some negative effects on the Achilles tendon.

    Research question/s:

    Do AAS, combined with an exercise programme, alter tendon remodelling in rats?



    40 Wistar rats.

    Experimental procedure:

    Rats were randomised and then grouped: sedentary (SED = 10), anabolic-androgenic steroids (AAS = 10; 5 mg/kg subcutaneously weekly), exercise training (EX = 10; 4 × 10 jumps each, overload of 50–70% of BW for 6 weeks) and AAS with training (AAS+EX). Following sacrifice, histology, gelatin zymography and serum corticosterone were measured. Activity of matrix metallopeptidases, a marker for tendon remodelling, was analysed in tissue extracts by zymography.

    Measures of outcome:

    Matrix metallopeptidase activity, inflammatory infiltrate, fibrosis, serum corticosterone.

    Main finding/s:

    • Histology: In the EX group, the most external layer that covers the tendon was thicker with aggregation of the collagen fibres, suggesting an increase in collagen synthesis, whereas in the AAS+EX group, an inflammatory infiltrate and fibrosis in tendons was observed as well as an increase of the serum corticosterone level.

    • was observed Exercise training upregulated matrix …

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