Article Text

Download PDFPDF
The I allele of the ACE gene is associated with improved exercise capacity in women with McArdle disease
  1. F Gómez-Gallego1,
  2. C Santiago1,
  3. M Morán2,
  4. M Pérez1,
  5. J L Maté-Muñoz1,
  6. M Fernández del Valle1,
  7. J C Rubio2,3,
  8. I Garcia-Consuegra2,3,
  9. C Foster4,
  10. I A L Andreu3,5,
  11. M A Martín2,
  12. J Arenas2,
  13. A Lucia1
  1. 1
    Universidad Europea de Madrid, Madrid, Spain
  2. 2
    Centro de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
  3. 3
    Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Spain
  4. 4
    Department of Exercise and Sport Science, University of Wisconsin-La Crosse, La Crosse, WI, USA
  5. 5
    Centre d’Investigacions en Bioquímica y Biología Molecular (CIBBIM), Hospital Universitari Vall d’Hebron, Barcelona, Spain
  1. Alejandro Lucia, Universidad Europea de Madrid (Polideportivo), E-28670 Villaviciosa de Odón, Madrid, Spain; alejandro.lucia{at}


Background: McArdle disease is an uncommon metabolic disorder usually characterized by marked exercise intolerance although great individual variability exists in its phenotypic manifestation.

Objective: The purpose of this study was to determine the association between angiotensin-converting enzyme (ACE) genotypes and indices of exercise capacity (peak oxygen uptake (VO2peak), ventilatory threshold (VT) and gross mechanical efficiency (GE)) in patients with McArdle disease. Based on previous research, it was hypothesized that the I allele might favourably influence exercise capacity.

Methods: Forty-four Spanish patients (23 males, 21 females) and 44 age-matched and gender-matched controls (23 males, 21 females) performed a graded cycle-ergometer test until exhaustion (for VO2peak and VT determination) and a 12 min constant-load test at the power output eliciting the VT (for GE determination).

Results: No significant difference (p>0.05) was found in indices of exercise capacity between ID + II genotypes and DD homozygotes in the group of male patients, male controls and female controls. However, in the group of female patients, the ID + II group (n = 11) had a higher VO2peak than DD homozygotes (n = 10) (15.8 (SEM 1.6) ml/kg/min versus 11.9 (SEM 0.9) ml/kg/min, respectively; p<0.05).

Conclusions: The I allele of the ACE gene is associated with a higher functional capacity in female patients, and might partly explain the individual variability in the phenotypic manifestation of McArdle disease.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding: MM and JCR are supported by contracts from Fondo de Investigaciones Sanitarias (FIS) CA05/0039 and CD06/00031, respectively (Ministerio de Sanidad y Consumo (MSC), Madrid), and MAM is supported by Programa de Intensificación de la Actividad Investigadora, ISCIII (MSC) and Agencia Laín Entralgo (Consejería de Sanidad, Comunidad de Madrid). This work was supported by grants from FIS numbers PI040487, PI041157 and PI050579.

  • Competing interests: None declared.