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Trp64Arg polymorphism in ADRB3 gene is associated with elite endurance performance
  1. Catalina Santiago1,
  2. Jonatan R Ruiz2,
  3. Amaya Buxens3,
  4. Marta Artieda3,
  5. David Arteta3,
  6. Marta González-Freire1,
  7. Gabriel Rodríguez-Romo4,
  8. Signe Altmäe5,
  9. José I Lao6,
  10. Félix Gómez-Gallego1,
  11. Alejandro Lucia1
  1. 1Universidad Europea de Madrid, Madrid, Spain
  2. 2Unit for Preventive Nutrition, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
  3. 3Progenika Biopharma, Parque Tecnológico de Zamudio, Derio-Vizcaya, Spain
  4. 4INEF, Universidad Politécnica de Madrid, Madrid, Spain
  5. 5Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
  6. 6Preventia Genetics, Parque Tecnológico de Zamudio, Derio-Vizcaya, Spain
  1. Correspondence to Dr Alejandro Lucia, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Madrid, Spain; alejandro.lucia{at}


In this study, allele and genotype frequencies of the ADRB1 Arg389Gly (rs1801253), ADRB2 Gly16Arg (rs1042713) and Gln27Glu (rs1042714), and ADRB3 Trp64Arg (rs4994) variations were compared in the following three groups of Spanish (Caucasian) men: (1) world-class endurance athletes (E; runners and cyclists, n=100), (2) elite power athletes (P; sprinters, jumpers and throwers, n=53) and (3) non-athletic controls (C; n=100). No significant differences were observed in genotype and allele distributions among the study groups except for the ADRB3 Trp64Arg polymorphism in E versus C (27% vs 8% of carriers of the Arg allele in E and C, p<0.001; frequency of the minor Arg (C) allele of 14% vs 4% in E and C, p=0.001). Heterozygosity for the ADRB3 Trp64Arg polymorphism seems to be associated with elite endurance performance, while other variants of the β-adrenergic receptors' genes do not seem to significantly influence top-level sports performance, at least in athletes of Spanish origin.

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  • CS and JRR contributed equally

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the Universidad Europea de Madrid.

  • Provenance and peer review Not commissioned; externally peer reviewed.