Statistics from Altmetric.com
Whether sickle cell trait (SCT) carriers are at greater risk for exertional death has been a subject of intense debate.1 Large epidemiological studies in warfighters2 and athletes3 clearly show an increased risk for exercise-related sudden death in SCT carriers compared with non-SCT carriers.
The pathogenesis of exertional death in SCT carriers is unknown.4 However, the mechanisms initiating these adverse events could be parallel to the ones involved in the vaso-occlusion crises in sickle cell disease (SCD). Vaso-occlusion in patients with SCD involves haemorheological alterations, inflammation, vascular-adhesion processes and endothelial dysfunction.5 Comparisons of exercise responses between SCT carriers and non-SCT carriers demonstrated slightly decreased red blood cell deformability, increased …
Competing interests None.
Provenance and peer review Not commissioned; externally peer reviewed.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.