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Repeated head trauma is associated with smaller thalamic volumes and slower processing speed: the Professional Fighters’ Brain Health Study
  1. Charles Bernick1,
  2. Sarah J Banks1,
  3. Wanyong Shin2,
  4. Nancy Obuchowski3,
  5. Sam Butler3,
  6. Michael Noback1,
  7. Michael Phillips2,
  8. Mark Lowe2,
  9. Stephen Jones2,
  10. Michael Modic2
  1. 1Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, Nevada, USA
  2. 2Department of Radiology, Cleveland Clinic, Cleveland, Ohio, USA
  3. 3Department of Qualitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA
  1. Correspondence to Dr Sarah J Banks, Lou Ruvo Center for Brain Health, Cleveland Clinic, 888 W Bonneville Ave, Las Vegas, Nevada 89106, USA; bankss2{at}ccf.org

Abstract

Objectives Cumulative head trauma may alter brain structure and function. We explored the relationship between exposure variables, cognition and MRI brain structural measures in a cohort of professional combatants.

Methods 224 fighters (131 mixed martial arts fighters and 93 boxers) participating in the Professional Fighters Brain Health Study, a longitudinal cohort study of licensed professional combatants, were recruited, as were 22 controls. Each participant underwent computerised cognitive testing and volumetric brain MRI. Fighting history including years of fighting and fights per year was obtained from self-report and published records. Statistical analyses of the baseline evaluations were applied cross-sectionally to determine the relationship between fight exposure variables and volumes of the hippocampus, amygdala, thalamus, caudate, putamen. Moreover, the relationship between exposure and brain volumes with cognitive function was assessed.

Results Increasing exposure to repetitive head trauma measured by number of professional fights, years of fighting, or a Fight Exposure Score (FES) was associated with lower brain volumes, particularly the thalamus and caudate. In addition, speed of processing decreased with decreased thalamic volumes and with increasing fight exposure. Higher scores on a FES used to reflect exposure to repetitive head trauma were associated with greater likelihood of having cognitive impairment.

Conclusions Greater exposure to repetitive head trauma is associated with lower brain volumes and lower processing speed in active professional fighters.

  • Neurology
  • Epidemiology
  • Concussion
  • Contact sports
  • Boxing/Kick Boxing

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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