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Contributors: CS and JS planned the outline of the review, wrote the manuscript, and edited subsequent drafts. MJA assisted in writing the manuscript and edited subsequent drafts.
Competing interests: We have read and understood the BMJ policy on declaration of interests and declare: CS is the recipient of a NHMRC practitioner fellowship (No 571084). JS is the recipient ofthe Elizabeth and Henry Hamilton-Browne scholarship from the University of Sydney. MJA is supported by the Mayo Clinic Windland Smith Rice comprehensive sudden cardiac death programme.
Provenance and peer review: Commissioned; not externally peer reviewed.
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