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Exploration and confirmation of factors associated with uncomplicated pregnancy in nulliparous women: prospective cohort study
  1. Lucy C Chappell1,
  2. Paul T Seed1,
  3. Jenny Myers2,
  4. Rennae S Taylor3,
  5. Louise C Kenny4,
  6. Gustaaf A Dekker5,
  7. James J Walker6,
  8. Lesley M E McCowan3,
  9. Robyn A North1,
  10. Lucilla Poston1
  1. 1Division of Women's Health, Women's Health Academic Centre, King's College London and King's Health Partners, UK
  2. 2Maternal and Fetal Health Research Centre, Manchester Academic Health Science Centre, University of Manchester and Central Manchester Foundation Trust, UK
  3. 3Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand
  4. 4The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Obstetrics and Gynaecology, University College Cork, Republic of Ireland
  5. 5Department of Obstetrics and Gynaecology, Lyell McEwin Hospital, University of Adelaide, Australia
  6. 6Reproduction and Perinatal Health Research Group, University of Leeds, St James University Hospital, Leeds, UK
  1. Correspondence to: L C Chappell; lucy.chappell{at}


STUDY QUESTION Which variables at 15 and 20 weeks' gestation, particularly those amenable to modification before pregnancy, are associated with a subsequent uncomplicated pregnancy?

SUMMARY ANSWER Normalising body mass index, increasing fruit intake before pregnancy, reducing blood pressure, stopping misuse of drugs, and being in paid employment are all associated with subsequent uncomplicated pregnancy outcomes.

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