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As clinicians facing the challenges associated with the interpretation of drug concentrations or clinical laboratory measures in our daily practice, the outbreak of adverse analytical findings reported on meldonium makes us wonder if the information on meldonium available to date is sufficient to adequately interpret such findings. An adequate interpretation of a drug concentration requires knowledge of its pharmacokinetic characteristics and profile over time, and this has not been studied fully for meldonium.
Available studies suggest that meldonium is eliminated mainly by the kidneys. Single dose administration showed …
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.