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Currently, one new case of all-cause dementia is detected every 4 seconds around the world.1 All-cause dementia prevalence is also expected to rise since the number one risk factor is age2 and the number of older adults worldwide is increasing.3 Thus, the current lack of effective pharmaceutical treatments for all-cause dementia is creating an urgency to develop non-pharmacological strategies to prevent, or at least delay, the onset and progression of the disease.4 As a result, lifestyle approaches have become an important line of scientific inquiry and public interest.
Increasing physical activity is one promising strategy to promote or maintain cognitive health in later life.5 Strong and accumulating empirical evidence suggests regular physical activity of an intensity ≥3.0 metabolic equivalents (METs) reduces the risk of all-cause dementia by 28%.6 Thus, meeting current physical activity guidelines for older adults of 150 min/week of moderate-to-vigorous physical activity (ie, activity of ≥3.0 METs) may help reduce all-cause dementia risk, prevent other comorbidities including type 2 diabetes and cardiovascular disease, and reduce all-cause mortality.7–9 Since most older adults are physically inactive (ie, do not engage in ≥150 min/week of moderate-to-vigorous physical activity) and fall short of these recommendations,10 increasing moderate-to-vigorous physical activity among older adults has become a public health priority. As such, it is estimated 17.7% of Alzheimer's disease cases could be prevented by recommended amounts of moderate-to-vigorous physical activity.11
Accumulating evidence also suggests high amounts of sedentary behaviour can increase morbidity and mortality risk.12 Sedentary behaviour is defined as any behaviour that incurs ≤1.5 METs and includes behaviours such as sitting, television watching and lying down.13 Sedentary behaviour is associated with numerous health risks including type 2 diabetes,14 cardiovascular disease15 and all-cause mortality.16 Given the risks of sedentary behaviour to health, recommendations for sedentary time suggest limiting discretionary sedentary time to <2 h/day and accumulating >2 h/day of light-intensity activity (ie, standing and light walking).17 ,18 Emerging evidence also suggests sedentary behaviour is associated with cognitive function; however, sedentary behaviour is a distinct behaviour from physical activity and thus a systematic review of the current epidemiological evidence is needed.19 ,20
While preliminary evidence suggests sedentary behaviour is associated with cognitive function, it is still unclear what the magnitude of this association is. For example, it is unclear if reducing sedentary behaviour is more important for long-term cognitive health than increasing physical activity. Such empirical evidence is crucial to increasing our understanding of how we can best promote healthy cognitive ageing through lifestyle approaches and determining whether public health should focus on reducing sedentary behaviour, increasing moderate-to-vigorous physical activity or both to reduce all-cause dementia prevalence. Thus, our objective was to systematically review the epidemiological evidence regarding how sedentary behaviour is associated with cognitive function throughout the adult lifespan.
Summary of search strategy
We conducted a systematic review regarding the association between sedentary behaviour and cognitive function. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement,21 we searched PubMed, PsycINFO, EBSCO and Web of Science between 1 January 1990 and 6 February 2016. Included in our search terms were the following keywords: sedentary behaviour terms (sedentary behaviour, physical inactivity, television time, TV time, screen time); cognition terms (cognition, cognitive function, brain function, executive function, memory, dementia, Alzheimer's disease) and age terms (older adults, elders, elderly, ageing, aged, 40+ years). This process was repeated until all search term combinations were performed. A sample of the search strategy used for studies investigating the association between sedentary behaviour and cognitive function is provided in figure 1A.
We selected peer-reviewed, published and observational studies that included adults aged 40 years and older that measured sedentary behaviour as an exposure and cognitive function as an outcome. Articles mentioning sedentary behaviour and cognition in either the title or abstract were initially included for full-text review.
Inclusion and exclusion criteria
We included studies if they were (1) observational studies (ie, cohort, case-control or cross-sectional); (2) peer reviewed and (3) published in the English language between 1 January 1990 and 6 February 2016. All studies included clearly described participants as adults aged 40 years and older at baseline assessment and measured sedentary behaviour at baseline assessment or over time with the purpose of assessing risk (ie, exposure). Additionally, the studies included measured cognitive function at baseline assessment or over time with the purpose of determining change associated with increased sedentary behaviour (ie, outcome).
We excluded articles if they were (1) not peer reviewed and (2) not published in the English language. Since we were only interested in observational studies, interventions designed to reduce sedentary behaviour were not included.
Two authors (RSF and JCD) initially screened and identified studies based on the study title and abstract. Duplicates and articles failing to meet inclusion criteria were removed. The remaining full-text articles were reviewed by RSF and JCD to determine eligibility. Any disagreements were resolved by a third reviewer (TL-A).
Two raters (RSF and JCD) independently extracted data from all articles included; discrepancies were discussed and reviewed by a third party (TL-A). Data were extracted from the included articles using a custom data extraction form developed by RSF and JCD. We extracted the following categories: (1) study design; (2) participant characteristics, setting and length of follow-up; (3) measure of exposure (ie, sedentary behaviour); (4) measure of outcome (ie, cognitive function) and (5) main findings.
For exposure measures (ie, sedentary behaviour), we extracted the (1) instrument name; (2) exposure definition (eg, sedentary behaviour or television time); (3) method of exposure assessment (eg, self-report questionnaire, accelerometry, etc); (4) data collection procedure; (5) statistical methodology and (6) previously established validity and reliability of the instrument. For exposure definitions, sedentary behaviour included time spent engaging in activities with an energy cost of ≤1.5 METs and television time referred to sedentary time spent watching television.
For methods of assessment of cognitive function, we extracted the (1) instrument name; (2) domain of cognitive function assessed; (3) method for assessing cognitive function; (4) statistical methodology and (5) previously established validity and reliability of the instrument. Given the limited number of studies available and the heterogeneity of samples used in these studies, we did not perform a meta-analysis.
Assessment of study quality
Two authors (RSF and JCD) assessed the quality of the articles via the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines.22 The STROBE checklist contains 22 separate items to identify the quality of reporting for observational studies. In summary, we assessed study quality based on the following components: (1) an informative and balanced abstract; (2) clear scientific background, rationale, objectives and hypothesis; (3) clear description of study design, methodology, outcomes and exposures, and statistical analyses; (4) clear description of potential biases and how these were limited; (5) clear description of study participants, incidence of loss to follow-up and reporting of outcomes and exposures; (6) clear reporting of all results and analyses; (7) clear summarisation of study findings with reference to study objectives; (8) clear description of the limitations of the study and (9) a cautious overall interpretation of the findings with reference to the generalisability of the findings.
Two raters (RSF and JCD) independently rated the quality of the studies and achieved consensus through discussion (Κ=0.90). Discrepancies were settled by a third author (TL-A). We used a binary system (+=Yes, −=No) for each item of interest on the STROBE checklist. High-quality studies were defined as studies missing fewer than three criteria of the STROBE checklist, while low-quality studies were defined as studies missing three or more criteria.
Search results and study characteristics
Figure 1A, B describes the results of the search strategy for articles examining the association of sedentary behaviour with cognitive function. Of the 485 articles initially identified by title and abstract screening, our final systematic review included 8 articles.23–30
Study characteristics are described in table 1. Three studies used a cohort design,23–25 one was a nested case-control design,26 one used a case-control design27 and three studies used a cross-sectional design.27–29 The average follow-up time for the cohort studies was 7.67 years,23–25 and the follow-up time for the nested case-control study was 21 years.26 Sample sizes ranged from 125 to 6359 participants with samples from England, Finland, France and the USA.
Measurement of sedentary behaviour
Measurement of sedentary behaviour varied considerably with a total of eight different measures used across the eight studies, as described in table 2. All eight studies measured exposure to sedentary behaviour via subjective methods,23–30 and one study28 measured sedentary behaviour via an objective method (accelerometry). Five studies measured exposure as sedentary time (ie, time spent sitting, lying down or sleeping)25–30 and four studies measured exposure as TV time.23–25 ,27 One study measured exposure as TV time and sedentary time.25
Five studies examined sedentary behaviour using a previously developed questionnaire.24 ,25 ,28–30 Two studies24 ,25 used the Modifiable Activity Questionnaire (MAQ) to assess sedentary behaviour,32 a single study29 used the Community Health Activities Model Program for Seniors (CHAMPS) questionnaire,42 another study28 used the Sedentary Behaviour Questionnaire (SBQ)39 and the last study30 used an unnamed questionnaire developed from previous investigations to assess sedentary time.44 Each of the four questionnaires showed evidence of validity and reliability; however, only the CHAMPS, MAQ and SBQ were previously validated against a criterion measure.39 ,47 ,50
A single study28 used an accelerometer, the ActiGraph GT3X+,40 to measure sedentary behaviour objectively. Accelerometers show good evidence of validity;48 ,49 however, there is no current minimum wear standard for reliable sedentary behaviour estimates.
Measurement of outcomes from sedentary behaviour
Table 3 describes the measures of cognitive function used. Thirteen different measures of cognitive function were used across the eight studies.23–30 Studies examined the following areas of cognition: (1) five measured memory;23 ,24 ,29 ,30 (2) five measured executive function;23–25 ,28 ,30 (3) four measured processing speed;23 ,28–30 (4) two measured incidence of cognitive impairment or all-cause dementia26 ,27 and (5) one measured perceptual organisation and planning.30 Three studies created scores for global cognitive function.23 ,29 ,30
Assessment of memory
The constructs of memory measured were non-descriptive memory (ie, unspecified by the authors as to what construct of memory the test measured), lexical-semantic memory, working memory, visual memory and episodic memory. Non-descriptive memory was measured via delayed word recall31 in one study23 and the Benton Visual Retention Test45 in another study.30 Lexical-semantic memory was measured via phonemic and semantic fluency36 in two studies.24 ,25 Working memory was measured by digit span forward and backward33 in two studies.24 ,25 Visual memory was assessed using the Rey-Osterrieth Complex Figure Copy and Recall Test46 in one study.30 Episodic memory was measured via the RI-48 test35 in two studies.24 ,25 Among the measures used, the Benton Visual Retention Test, phonemic and semantic fluency, digit span forward and backward, Rey-Osterrieth Complex Figure Copy and Recall Test and the RI-48 have evidence of validity and reliability.46 ,35 ,51 ,52
Assessment of executive function
Two studies24 ,25 used the Delis-Kaplan Trail Making Test34 to assess executive function, one study23 used verbal fluency31 and two studies28 ,30 used Trail Making Test.41 The Delis-Kaplan Trail Making Test and the Trail Making Test have evidence of validity and reliability.41 ,53 ,54
Assessment of processing speed
Assessment of cognitive impairment and all-cause dementia incidence
One study26 used the Mini-Mental State Examination37 to screen for cognitive impairment and then conducted neuropsychological examinations to screen for all-cause dementia according to the Diagnostic and Statistical Manual of Mental Disorders.38 The other case-control study27 screened for cases of Alzheimer's disease using unstated neuropsychological, laboratory and neurological examinations. Evidence of validity and reliability exists for the Mini-Mental State Examination.37
Assessment of perceptual organisation and planning
The study30 measuring perceptual organisation and planning used the Rey-Osterrieth Complex Figure Copy and Recall Test.46 Evidence of validity and reliability exists for the Rey-Osterrieth Complex Figure and Recall Test.46
Assessment of global cognitive function
One study29 used the CogState43 computerised battery to assess global cognitive function. Another study23 created a standardised global cognitive function score from the three cognitive measures used in the study: immediate word recall, delayed word recall and verbal fluency.31 The final study30 to measure global cognitive function used a standardised score from the Benton Visual Retention Test,45 Trail Making Test41 and Rey-Osterrieth Complex Figure Copy and Recall Test.46 Only the CogState computerised battery has evidence of validity and reliability as a global cognition measure.55
Studies varied considerably in quality as shown in table 4. On average, studies met 19 of the 22 specific criteria of the STROBE checklist.23–30 One article met all guidelines for the reporting of information;24 however, three studies failed to address four or more different criteria of the STROBE checklist.27–29 All four of the high-quality studies found negative associations between sedentary behaviour and cognitive function.23–26
The common issues were failure to report (1) study size (n=4);27–30 (2) information about the design in the title and abstract (n=4);26 ,28–30 (3) potential biases (n=4)27–30 and (4) specific objectives and hypotheses (n=3).23 ,26 ,29 Other issues in study quality included failure to report (1) eligibility criteria (n=1);27(2) sources of data and method of assessment (n=1);27 (3) describing statistical analyses (n=1);25 (4) providing a cautious overall interpretation of the study (n=1);28 (5) discussing the generalisability of the findings (n=1)28 and (6) outcomes, exposures and potential confounders (n=1).28
Findings from studies on the association of sedentary behaviour with cognitive function
In total, six studies found associations between increased sedentary behaviour and decreased cognitive function.23–28 Two studies found associations between increased sedentary behaviour and improved cognitive function.28 ,30
Among the cohort studies, one study found an association between increased sedentary behaviour and decreased cognitive function over time.24 The other two studies found associations between increased sedentary behaviour and lower cognitive function at baseline, but no association between sedentary behaviour and cognition over time.23 ,25
The nested case-control study found the odds of developing all-cause dementia were higher for individuals who engaged in more sedentary behaviour.26 In addition, the other case-control study found that individuals who watched more hours of television per day had higher odds of developing Alzheimer's disease in later life.27
The results of the cross-sectional studies were mixed. One study found associations between increased sedentary behaviour and lower cognitive function.29 A second study found sedentary behaviour was positively associated with cognitive function.30 The final cross-sectional study found subjectively measured sedentary behaviour was positively associated with processing speed; however, there was no association between sedentary behaviour and cognitive function when measured objectively.28
Summary of main findings
Our results indicate sedentary behaviour is associated with reduced cognitive function over the lifespan. Importantly, all four of the high-quality studies found sedentary behaviour is associated with poorer cognitive function. However, the heterogeneity in the current methods used to quantify sedentary behaviour and cognitive function is the major barrier to determining the precise magnitude of this relationship. We also found only one study used an objective measure of sedentary behaviour and a number of exposure measures lacked evidence of validity and reliability.
Furthermore, two of the three longitudinal studies had follow-up periods of <10 years, which may account for the significant findings at baseline but not over time.23 ,25 Changes in cognition occur gradually over the adult lifespan,56 often with detectable changes occurring after the age of 60.57 As such, studies with short-term follow-ups (ie, <10 years) may not detect meaningful associations between changes in cognition and lifestyle behaviours.
Comparison of the findings with the literature
A large body of work on the association between physical activity and improved cognitive function exists6; however, far less is known about the association of sedentary behaviour with cognition. Some preliminary findings have suggested that sedentary behaviour is associated with later-life cognitive impairment but have also noted a lack of epidemiological evidence needed to draw strong conclusions.19 ,20
Our review suggests sedentary behaviour is indeed associated with impaired cognitive function and all-cause dementia risk. Specifically, higher quality studies23–26 and those of stronger epidemiological evidence (ie, cohort or case-control design)23–27 all found associations between increased sedentary behaviour and poorer cognition. Moreover, the current evidence suggests an association by meeting five of the nine epidemiological criteria for causation.58 Specifically, the criteria met include: (1) consistent findings across persons, places and circumstances; (2) evidence of temporality; (3) evidence of a dose–response relationship; (4) a plausible mechanism by which exposure leads to outcome and (5) by analogy, the exposure is associated with outcome. Importantly, our systematic review found consistency in the findings,23–29 evidence of temporality24 ,26 ,27 and evidence of a dose–response relationship.23–25 ,29
In addition to our findings, a plausible mechanism by which sedentary behaviour is associated with cognitive decline is emerging. Recent data suggest prolonged sedentary time impairs glucose and lipid metabolism,59 which are both recognised as risk factors for cognitive decline and all-cause dementia.60 ,61 There is also evidence that sedentary behaviour is related to cognitive decline by analogy. Briefly, sedentary behaviour is associated with many chronic diseases14 ,15 ,16 ,62 which are also associated with cognitive impairment and dementia risk.63–65 Thus, the evidence collectively suggests sedentary behaviour is a risk factor for later-life cognitive impairment and all-cause dementia risk.
Assessment of sedentary behaviour
While our findings suggest there is now enough evidence to consider sedentary behaviour a risk factor for cognitive decline and dementia, the current measurement of sedentary behaviour still has some limitations. First, only one of the studies reviewed measured sedentary behaviour with an objective measure.28 While there is no one best measure for assessing sedentary behaviour,66 and objective measures and subjective measures have limitations,67 objective measures are considered to be more accurate and reliable because they eliminate recall bias.68 This is because physical activity participation among older adults is often intermittent, sporadic or unstructured, which makes recall extremely difficult;69 thus, older adults may unintentionally over-report their sedentary behaviour.70 However, this does not mean subjective methods of assessing sedentary behaviour are useless. Complete data from objective measures have an inherent selection bias which limits the generalisability of the findings, and objective assessment may miss components or dimensions of sedentary behaviour which may be health protective.68 Thus, future research examining the association of sedentary behaviour with cognitive function should use both objective and subjective measures whenever possible.71
Second, four of the eight studies we reviewed used measures of sedentary behaviour with no previous evidence of validity or reliability.23 ,26 ,27 ,30 Validity and reliability are important for making sound interpretations from tests, and thus the lack of evidence of either calls into question the conclusions drawn from these studies.72 ,73 The continued use of measures without evidence of validity and reliability is making the conclusions drawn from these studies questionable at best, and downright wrong at worst.74
Finally, the construct of sedentary behaviour was misclassified in several of the studies. For example, Kivipelto et al26 categorised participants as sedentary based on self-reported leisure-time physical activity of less than twice per week. Yet, the absence of physical activity does not define sedentary behaviour,14 and thus misclassification in the literature poses challenges to accurately assessing the association between sedentary behaviour and cognitive function.
Assessment of cognitive function
While the current measurement of cognitive function in the studies reviewed appears to be more rigorous than the methods used to assess sedentary behaviour, there are still concerns. First, the numerous measures of cognitive function currently in use are obfuscating the relationship between sedentary behaviour and cognition. The eight studies we reviewed used a total of 13 measures of cognitive function. Specifically, the studies assessed memory by six different tests, executive function by four tests, processing speed by two methods, cognitive impairment by two methods and global cognitive function by three methods. With such a wide variety of measures used to assess each domain of cognitive function, comparing study results is extremely difficult. On the basis of the heterogeneity of measures, we recommend future studies use the following instruments for each domain of cognition to allow comparisons across studies: (1) RI-48 for memory; (2) Trail Making Task for executive function; (3) immediate word recall for processing speed; (4) the Rey-Osterrieth Complex Figure Copy and Recall Test for perceptual organisation and planning and (5) the Montreal Cognitive Assessment (MoCA)75 for global cognition.
In addition, the numerous domains of cognition being assessed (ie, global cognition, memory, executive function, etc) prevent comparisons of study results. Few studies tested similar domains of cognition, and thus it is unclear if sedentary behaviour is associated with decrease in global cognitive function, several different domains of cognition or just a single domain. Future studies therefore need to first determine which domains of cognitive function decrease with increased sedentary behaviour. One means of potentially assessing all domains of cognitive function concomitantly would be the use of the NIH toolbox,76 which could independently examine the associations of sedentary behaviour with memory, executive function, and so forth.
Several of the measures used to assess cognitive function in these studies also lacked evidence of validity or reliability, and thus the conclusions may not be valid for the construct the authors planned to investigate.77 For example, Hamer and Stamatakis23 used a memory test (ie, delayed word recall) without evidence of validity or reliability; thus, rather than measuring memory, the test may be related to another construct, such as executive function.
While there are some issues with measurement of cognitive function in these studies, our preliminary findings suggest sedentary behaviour is negatively associated with memory, executive function and global cognition. These findings suggest sedentary behaviour has a similar association with cognition as exercise and moderate-to-vigorous physical activity. Moderate-to-vigorous physical activity, as well as aerobic and resistance exercise, is well documented to affect multiple domains of cognitive function.78 Furthermore, moderate-to-vigorous physical activity and exercise are established as an all-cause dementia prevention measure which could reduce the incidence of all-cause dementia by as many as 1 million cases worldwide.79 Given this information, sedentary behaviour may be adversely associated with the same neurophysiological pathways as moderate-to-vigorous physical activity and exercise.
The STROBE checklist for observational studies is designed to ensure important information on study design is available, so readers of research can follow what was planned, what was done, what was found and what conclusions can be drawn.22 This information is an important component for systematic reviews;80 ,81 however, when components required by the STROBE guidelines are absent, the conclusions which can be drawn from these studies suffer.
The quality of studies we reviewed varied greatly with several of the studies showing multiple flaws in reporting. Only one study24 met all criteria of the STROBE, and several studies were missing multiple criteria. Issues such as sampling bias, selection bias, recall bias and detection bias may therefore have inflated the results of these studies. We therefore recommend future investigations on how sedentary behaviour is associated with cognitive function firmly adhere to the STROBE guidelines.
Finally, the lack of a sample size calculation by any of the studies we reviewed is an important concern. Sample size calculations for observational studies require a compromise between balancing the needs of power, economy and timeliness.82 Failure to attain a sample size with enough power inevitably leads to type II error; however, equally erroneous is using a sample size that is ‘too big’ that detects an effect of little scientific importance.83 For example, one study we reviewed included well over 6000 participants23 which may have accounted for the significant, albeit small, results.
Current physical activity guidelines offer a brief policy recommendation on sedentary behaviour—avoid it as much as possible;84 ,85 however, in order to best promote healthy cognitive ageing, an empirically derived public health message is still needed. Thus, we have developed healthy cognitive ageing guidelines for sedentary behaviour which are in line with current evidence and recommendations.17 ,18 ,85 ,86 We therefore recommend all adults should (1) avoid sedentary time wherever possible; (2) limit discretionary sitting time to <2 h/day; (3) stand up and move after 30 min of uninterrupted sitting and (4) increase light-intensity activity (ie, standing and light walking) to >2 h/day by substituting these activities for sedentary time (eg, stand while watching television).
Combating a sedentary lifestyle—and associated cognitive declines—also requires an emphasis on encouraging adults to engage in ≥150 min/week of moderate-to-vigorous physical activity. Regular moderate-to-vigorous physical activity is a pillar of healthy cognitive ageing, with current evidence suggesting ≥150 min/week of moderate-to-vigorous physical activity reduces the risk of Alzheimer's disease by 38%.87 Moreover, empirical evidence has found a strong and consistent relationship between moderate-to-vigorous physical activity and cognitive function. Given the current evidence, we recommend all adults limit discretionary sedentary behaviour to <2 h/day and concomitantly engage in ≥150 min/week of moderate-to-vigorous physical activity. Meeting these recommendations may best promote healthy cognitive ageing and could reduce the incidence of all-cause dementia by more than 1 million cases worldwide.6
Limitations and future directions
This review only investigated observational studies on how sedentary behaviour is associated with cognitive function; however, to our knowledge, this is the first systematic review to evaluate the evidence. There may also be a publication bias which limits the generalisability of our findings; however, this limitation is inherent in all systematic reviews. Our systematic review located only eight studies, but our findings do show a consistent relationship that sedentary behaviour is associated with poorer cognitive function. Although all four high-quality studies found sedentary behaviour is associated with poorer cognition,23–26 more high-quality studies are needed before estimates can be made about the attributable risk of sedentary behaviour to cognitive impairment and all-cause dementia.
Given this area of research is still developing, our study only provides an initial platform for examining the association of sedentary behaviour with cognitive impairment and all-cause dementia. Our preliminary recommendations for healthy cognitive ageing are therefore broadly consistent with current policy17 ,18 ,85 ,86 and may need to be refined as more evidence emerges.
Dementia is also a complex disease which has several forms including Alzheimer's disease and vascular dementia, which have vastly different aetiologies. While the mechanisms may be different by which the different subtypes of dementia occur, there are certainly similarities in terms of risk factors. For example, Laurin and colleagues found increased moderate-to-vigorous physical activity was associated with reduced risks of cognitive impairment and dementia of any type.87 Thus, our preliminary findings suggest reduced cognitive function and increased all-cause dementia risk are associated with a sedentary lifestyle. Future studies should determine the associations of sedentary behaviour with different types of dementia.
Related to this issue, different types of sedentary behaviour may have different associations with cognitive function. For example, there is some evidence that computer use may positively affect cognitive function in later life.24–26 However, since only eight studies assessing sedentary behaviour were included in this review—and only three studies24–26 assessed computer use as an exposure variable—it would be difficult to make comparisons and draw conclusions from the available literature. Future studies are therefore needed to determine how different sedentary activities, such as computer use, moderate the relationship between sedentary behaviour and cognitive function.
The current body of evidence suggests sedentary behaviour is negatively associated with cognitive function; however, the associations between sedentary behaviour and cognitive function are complex and largely dependent on the exposure variable and outcomes assessed. Nonetheless, our findings suggest reducing discretionary sedentary time to <2 h/day and concomitantly engaging in ≥150 min/week of moderate-to-vigorous physical activity may best promote healthy cognitive ageing.
Determining the association of sedentary behaviour with cognitive function could help guide public health policy on how to best promote healthy cognitive ageing.
Our results indicate greater amounts of sedentary behaviour are associated with reduced cognitive function over the lifespan.
Limiting discretionary sedentary behaviour to <2 h/day and concomitantly engaging in ≥150 min/week of moderate-to-vigorous physical activity may be crucial to maintaining cognitive health throughout the lifespan.
This work was supported by funding from the Jack Brown and Family Alzheimer Research Foundation Society. RSF is funded by the University of British Columbia Rehabilitation Sciences Doctoral Award. JCD is a Canadian Institutes of Health Research postdoctoral fellow. TL-A is a Canada Research Chair in Physical Activity, Mobility and Cognitive Neuroscience.
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