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Circulating microrna as novel early biomarker of concussion in elite athletes
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  • Published on:
    Update on Fluid-Based Biomarkers in Sports-Related Concussion Diagnosis
    • Matthew J Rogatzki, Assistant professor Appalachian State University, Boone, NC, USA
    • Other Contributors:
      • Gareth Irwin, Professor and Head of Sports Biomechanics
      • Geneieve KR Williams, Lecturer
      • Jiao Jiao, Post-doctoral Research Fellow
      • Wei Liang, Post-doctoral Research Fellow
      • Binh Quach, Technical Director
      • Rongjun Yu, Associate Professor
      • Huw Wiltshire, Principal Lecturer and and Associate Dean of Enterprise in the Cardiff School of Sport
      • Julien S. Baker, Head and Professor, Director, Centre for Health and Exercise Science Research

    Introduction

    Recently, an article by Di Pietro and colleagues investigating small non-coding RNAs (sncRNA)s in the saliva of concussed rugby players was published in the British Journal of Sports Medicine (BJSM), a highly rated sports medicine journal [1]. Due to the groundbreaking nature of the study, many media outlets published articles celebrating the authors’ findings. One such article from the Washington Post was titled: “Concussions can be diagnosed through a saliva test, British researchers find.”[2]. As a result, colleagues and clinicians have contacted members of the Sport and Health Interdisciplinary group in Movement & Performance from Acute & Chronic head Trauma (IMPACT), a recently formed international group investigating concussion injury, asking our opinion of the article and what the findings mean for sports-related concussion (SRC) diagnosis. Similar questions emerged in 2018 when the United States of America Food and Drug Administration (FDA) announced approval of a blood test using glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl-terminal esterase L1 (UCHL1) to differentiate between computed tomography (CT)-positive and CT-negative results. The headline for this announcement read: “FDA authorizes marketing of first blood test to aid in the evaluation of concussion in adults,”[3] which led to confusion among clinicians as to what this meant for concussion assessment and diagnosis. Therefore, the interdisciplinary IMPACT team t...

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    Conflict of Interest:
    None declared.