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Exercise training may improve the tumour microenvironment after breast cancer (PEDro synthesis)
  1. Vincent Singh Paramanandam1,
  2. Vincent S Prema2
  1. 1Department of Physiotherapy, Tata Memorial Hospital, Mumbai, Maharashtra, India
  2. 2Department of Physiotherapy, Vashani Diagnostic Centre, Mumbai, Maharashtra, India
  1. Correspondence to Dr Vincent Singh Paramanandam, Physiotherapy Department, MBG 96, Tata Memorial Hospital, Dr E Borges Marg, Mumbai 400012, India; vinsu24{at}

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Meneses-Echavez JF, Correa-Bautista JE, Gonzalez-Jimenez E, et al. Cancer Epidemiol Biomarkers Prev. 2016;25:1009–17.


Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths in women worldwide.1 Many studies show a relationship between exercise behaviour and breast cancer prognosis. Additionally, more recent research reports a relationship between fitness and disease-free survival in women with breast cancer.2 However, there is paucity of evidence exploring the various mechanisms underlying the exercise-prognosis relationship in cancer. This systematic review addressed one possible mechanism: the effect of exercise training on inflammatory mediators.


This systematic review aimed to quantitatively analyse the effect of exercise training on inflammatory biomarkers in breast cancer survivors.

Searches and inclusion criteria

PubMed, CENTRAL, Embase and Scopus were searched with search terms related to breast cancer, exercise and inflammatory mediators. In addition, six relevant journals and conference abstracts from the American Society of Clinical Oncology website from 2004 to 2013 were searched. Moreover, reference lists of the included studies were examined, and …

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  • Contributors Both authors selected the systematic review. VSP wrote the first draft of the manuscript. Both authors (VSP and PSV) contributed to the interpretation of the data and revision of drafts, approved the final manuscript and are guarantors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Correction notice This paper has been amended since it was published Online First. Table 1 was inadvertently omitted by the typesetter and this has now been reinstated.

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