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Recently, we read with great interest the paper by Zheng et al,1 in which the authors who performed an excellent meta-analysis concluded that aerobic exercise had a physiological benefit to improve cognitive function in patients with mild cognitive impairment. We appreciate this finding and would like to present a hypothesis that myokine triggered by physical aerobic exercises might also play a pivotal role in the improvement of cognitive impairment.
Physical exercise is of great importance to the health of brain. Increasing evidence shows that regular exercise could increase the activity of skeletal muscle and, as a …
Funding This study was supported by the Programme of Bureau of Science and Technology Foundation of Changzhou (number CJ20159022) and Major Science and Technology Projects of Changzhou Municipal Committee of Health and Family Planning (number ZD201505). BZ was supported by Changzhou High-Level Medical Talents Training Project.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.