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What did I do?
I investigated the impact of exercise on knee joint articular cartilage. This aim was investigated in three different systematic reviews (SRs) of randomised controlled trials (RCTs) in healthy animals and in humans at risk of or with knee osteoarthritis (OA).
Why did I do it?
Exercise is the first-line treatment for knee OA.1 Yet, many people still believe that exercise may ‘wear down my knee’ creating a barrier to exercise.
Articular cartilage is the hallmark of OA and the structure I studied in my PhD. It is a connective tissue that covers bone ends in the joints and provides lubrication of the meeting surfaces, allowing the transmission of loads with a low frictional coefficient. Aggrecan, collagen and molecular biomarkers are the molecules responsible for maintaining cartilage integrity, function and metabolism, and …
Funding This study is funded by European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN; KNEEMO) (607510).
Competing interests None declared.
Patient consent Not required.
Provenance and peer review Not commissioned; internally peer reviewed.