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Do the associations of sedentary behaviour with cardiovascular disease mortality and cancer mortality differ by physical activity level? A systematic review and harmonised meta-analysis of data from 850 060 participants
  1. Ulf Ekelund1,2,
  2. Wendy J Brown3,
  3. Jostein Steene-Johannessen1,4,
  4. Morten Wang Fagerland1,5,
  5. Neville Owen6,7,
  6. Kenneth E Powell8,
  7. Adrian E Bauman9,
  8. I-Min Lee10,11
  1. 1 Department of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway
  2. 2 Department for Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway
  3. 3 Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Queensland, Australia
  4. 4 Department of Health Sciences, Kristiania University College, Oslo, Norway
  5. 5 Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway
  6. 6 Behavioural Epidemiology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
  7. 7 Health, Arts and Design, Swinburne University of Technology, Melbourne, Victoria, Australia
  8. 8 Retired
  9. 9 Prevention Research Collaboration, School of Public Health and Charles Perkins Centre, Sydney University, Sydney, New South Wales, Australia
  10. 10 Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
  11. 11 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
  1. Correspondence to Professor Ulf Ekelund, Department of Sport Medicine, Norwegian School of Sport Sciences, Olso 0806, Norway; Ulf.Ekelund{at}nih.no

Footnotes

  • Contributors All authors contributed to the design of the study, generated hypotheses, interpreted the data and wrote and critically reviewed the report. UE lead the work of the writing group and wrote the first draft of the manuscript. JS-J and UE did the literature search. MWF analysed the data. MWF, JS-J, and UE had full access to study level data from all contributing studies.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Ethics approval This is a systematic review and meta-analysis of studies which all have been individually approved by their respective ethical review boards.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement We can not share any data as we do not have access to individual level data from participating studies.

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Footnotes

  • Contributors All authors contributed to the design of the study, generated hypotheses, interpreted the data and wrote and critically reviewed the report. UE lead the work of the writing group and wrote the first draft of the manuscript. JS-J and UE did the literature search. MWF analysed the data. MWF, JS-J, and UE had full access to study level data from all contributing studies.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Ethics approval This is a systematic review and meta-analysis of studies which all have been individually approved by their respective ethical review boards.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement We can not share any data as we do not have access to individual level data from participating studies.

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