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Contributors DV obtained and analysed the data and drafted the manuscript under the supervision of Luis Gracia-Marco (principal investigator), Alan R Barker and Craig A Williams.
Funding This project was funded by the European Union Seventh Framework Programme FP7/2007-2013 under grant agreement number PCIG13-GA-2013-618496.
Competing interests None declared.
Patient consent Obtained.
Ethics approval (1) Ethics Review Sector of Directorate-General of Research (European Commission, reference number 618496); (2) National Research Ethics Service Committee (NRES Committee South West–Cornwall and Plymouth, reference number 14/SW/0060).
Provenance and peer review Not commissioned; externally peer reviewed.
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