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What did I do?
The main aims of this PhD were (1) to study the association of the shed form of the α-Klotho gene (S-Klotho) with physical fitness, energy metabolism and cardiometabolic health, and (2) to study the effect of different exercise training programmes on S-Klotho, as well as on physical fitness, energy metabolism and cardiometabolic health in sedentary middle-aged adults.1
Why did I do it?
Since the discovery of the Klotho gene as a suppressor of several ageing phenotypes, numerous studies have focused on elucidating the molecular pathways that mediate the effects of its expression on cellular ageing–related processes.1 However, the role of the S-Klotho protein in different healthy ageing–related outcomes has not been deeply studied. Moreover, there is a biological base supporting the hypothesis that exercise training could induce an increment of S-Klotho, resulting in one of the still unrecognised physiological mechanisms that can explain the exercise benefits on the ageing process. …
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Contributors FJA-G contributed to the design and implementation of the research, to the analysis of the results and to the writing of the manuscript.
Funding The author of the current manuscript was supported by the Spanish Ministry of Education, Culture and Sports (FPU14/04172).
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval Ethics Committee on Human Research of the Regional Government of Andalusia (0838-N-2017).
Provenance and peer review Not commissioned; externally peer reviewed.