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  • Association of physical activity with all-cause and cardiovascular mortality in 7666 adults with hypertrophic cardiomyopathy (HCM): more physical activity is better

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Association of physical activity with all-cause and cardiovascular mortality in 7666 adults with hypertrophic cardiomyopathy (HCM): more physical activity is better
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  • Published on: 18 October 2020
    Physical activity in hypertrophic cardiomyopathy - be careful in genotype and troponin positive subgroup of patients.
    • Paweł P Dimitrow, Cardiology Professor 2nd Department of Cardiology, Jagiellonian University Medical College, Jakubowskiego 2 Str., 30-688 Krakow
    • Other Contributors:
      • Renata Rajtar-Salwa, Cardiologist
      • Tomasz Tokarek, Cardiologist

    Correspondence to: Paweł Petkow Dimitrow, 2nd Department of Cardiology, Jagiellonian University Medical College, Jakubowskiego 2 Str., 30-688 Krakow, Poland, e-mail: dimitrow@mp.pl, tel. 0048 12 400 22 50

    In recently published paper (1) authors showed that moderate-to-vigorous-intensity physical activity in adult population of patients with hypertrophic cardiomyopathy (HCM) (mean age 59.5 years) was associated with progressive reduction of all-cause and cardiovascular mortality. Authors suggested that the impact of physical activity on this population requires further investigation. This suggestion seems to be crucial because evaluated adult patients might be predominantly genotype-negative. In paper by Canepa et al. (2) percent of patients with positive genotype for HCM dynamically decreased over time.
    Additionally, in all three groups according to the tertiles of increasing physical activity the percent of patients with co-diagnosed arterial hypertension was very high (66-67%) (1). This fact may suggest that left ventricle (LV) hypertrophy is not primary type (HCM) but secondary to hypertensive stimulation. Accordingly, univariate and multivariate analyses in Bos et al. paper (3) demonstrated echocardiographic reversed septal curvature, age at diagnosis < 45 years, maximal LVWT ≥ 20 mm, family history of HCM, and family history of SCD to be positive predictors of positive genetic test while hypertension was a negativ...

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    Conflict of Interest:
    None declared.