Footnotes

• Twitter @dr_cindy_b, @STSkou, @UBC_CogMobLab

• Contributors All authors contributed to the conception and design on this paper. TLA, CKB and RSF drafted the work and STS provided substantial feedback on content and edits. All authors approve the final version.

• Funding Canadian Institutes of Health Research (MOP-142206 and PJT-148902) to TLA. STS is currently funded by a grant from Region Zealand (Exercise First) and a grant from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement no. 801790). TLA is a Canada Research Chair in Physical Activity, Mobility and Cognitive Neuroscience. CKB is an Alzheimer Association of USA and Brain Canada Postdoctoral Fellow. Content for this commentary was in part generated from a workshop (May 2019) hosted by the Physical Activity for Precision Health (PA4PH) Research Cluster (https://activehealth.ubc.ca/), University of British Columbia, Vancouver, BC, Canada. STS is associate editor of Journal of Orthopaedic & Sports Physical Therapy, he has received grants from The Lundbeck Foundation, personal fees from Munksgaard, all outside the submitted work. He is cofounder of Good Life with Osteoarthritis in Denmark (GLA:D), a not-for profit initiative hosted by the University of Southern Denmark aimed at implementing clinical guidelines for osteoarthritis in clinical practice.

• Patient consent for publication Not required.

• Provenance and peer review Not commissioned; externally peer reviewed.