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Four weeks of Corticosteroid inhalation does not augment maximal power output in endurance athletes
  1. Harm Kuipers (harm.kuipers{at}
  1. University of Maastricht, Netherlands
    1. Geert AC Van 't Hullenaar (g.vanthullenaar{at}
    1. University of Maastricht, Netherlands
      1. Babette M Pluim (b.pluim{at}
      1. KNLTB, Netherlands
        1. Shelley E Overbeek (soverbeek{at}
        1. Bronovo Hospital, Netherlands
          1. Olivier De Hon (o.dehon{at}
          1. Anti-Doping Authority the Netherlands, Netherlands
            1. Eric J Van Breda (eric.vanbreda{at}
            1. University of Maastricht, Netherlands
              1. Luc C Van Loon (l.vanloon{at}
              1. University of Maastricht, Netherlands


                Objective: To assess possible ergogenic properties of corticosteroid administration.

                Design: A balanced, double blind, placebo-controlled design was used.

                Participants: Twenty-eight well-trained cyclists and rowers.

                Intervention: Four weeks daily inhalation of 800 μg budesonide or placebo.

                Main outcome measurements: The subjects performed three incremental cycle ergometer tests until exhaustion, before and after two and four weeks of placebo or budesonide administration, to measure maximal power output (Wmax). Once a week they filled in a profile of mood state (POMS) questionnaire.

                Results: There was no significant difference in Wmax between the placebo (376±25 watt) and the corticosteroid group (375±36 watt) during the pre-intervention test, and there were no significant changes in either group after two and four weeks of intervention. No effect of the intervention on mood state was found.

                Conclusion: Four weeks of corticosteroid or placebo inhalation in healthy, well-trained athletes did not affect maximal power output or mood state. Hence no ergogenic properties of four weeks corticosteroid administration could be demonstrated, which corroborates previous studies with short-term corticosteroid administration.

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