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Randomised controlled trials (RCTs) are widely recognised as the strongest scientific approach to measuring the effects of interventions. If a clinician chooses to ignore evidence from RCTs to make clinical decisions and rely only on clinical observation, overestimation of treatment effects is very likely to occur. The latter occurs because changes in outcomes and the effects of interventions are completely different constructs.
RCTs control for confounding
Change in a given outcome is all a clinician can observe in clinical practice, and is basically the difference between an outcome measured after the intervention compared with the baseline assessment (ie, within-group difference). However, there are a number of factors that play a key role on the changes in outcomes. These factors are scientifically known as confounders and include (1) natural history, (2) regression to the mean, (3) placebo effect, (4) polite patients and (5) recall bias. Improvements observed in patients in clinical practice are contaminated with these …
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