@article {Kiadaliri558, author = {Aliasghar A Kiadaliri and Martin Englund and L Stefan Lohmander and Katarina Steen Carlsson and Richard B Frobell}, title = {No economic benefit of early knee reconstruction over optional delayed reconstruction for ACL tears: registry enriched randomised controlled trial data}, volume = {50}, number = {9}, pages = {558--563}, year = {2016}, doi = {10.1136/bjsports-2015-095308}, publisher = {British Association of Sport and Excercise Medicine}, abstract = {Background To analyse 5-year cost-effectiveness of early versus optional delayed acute anterior cruciate ligament (ACL) reconstruction.Methods 121 young, active adults with acute ACL injury to a previously uninjured knee were randomised to early ACL reconstruction (n=62, within 10 weeks of injury) or optional delayed ACL reconstruction (n=59; 30 with ACL reconstruction within 6{\textendash}55 months); all patients received similar structured rehabilitation. Real life data on health care utilisation and sick leave were obtained from regional and national registers. Costs and quality-adjusted life years (QALYs) were discounted at 3\%. Full-analysis set (based on study randomisation) and as-treated analysis (according to actual treatment over 5 years) principles were applied.Results Mean cost of early ACL reconstruction was {\texteuro}4695 higher than optional delayed ACL reconstruction (p=0.19) and provided an additional 0.13 QALYs (p=0.11). Full-analysis set showed incremental net benefit of early versus optional delayed ACL reconstruction was not statistically significantly different from zero at any level. As-treated analysis showed that costs for rehabilitation alone were {\texteuro}13 650 less than early ACL reconstruction (p\<0.001). Results were robust to sensitivity analyses.Conclusions In young active adults with acute ACL injury, a strategy of early ACL reconstruction did not provide extra economic value over a strategy of optional delayed ACL reconstruction over a 5-year period. Results from this and previous reports of the KANON-trial imply that early identification of individuals who would benefit from either early ACL reconstruction or rehabilitation alone might reduce resource consumption and decrease risk of unnecessary overtreatment.Trial registration ISRCTN84752559.}, issn = {0306-3674}, URL = {https://bjsm.bmj.com/content/50/9/558}, eprint = {https://bjsm.bmj.com/content/50/9/558.full.pdf}, journal = {British Journal of Sports Medicine} }