@article {Toohey1670, author = {Liam A Toohey and Michael K Drew and Jill L Cook and Caroline F Finch and Jamie E Gaida}, title = {Is subsequent lower limb injury associated with previous injury? A systematic review and meta-analysis}, volume = {51}, number = {23}, pages = {1670--1678}, year = {2017}, doi = {10.1136/bjsports-2017-097500}, publisher = {British Association of Sport and Excercise Medicine}, abstract = {Background Previous injury is a strong risk factor for recurrent lower limb injury in athletic populations, yet the association between previous injury and a subsequent injury different in nature or location is rarely considered.Objective To systematically review data on the risk of sustaining a subsequent lower limb injury different in nature or location following a previous injury.Methods Eight medical databases were searched. Studies were eligible if they reported lower limb injury occurrence following any injury of a different anatomical site and/or of a different nature, assessed injury risk, contained athletic human participants and were written in English. Two reviewers independently applied the eligibility criteria and performed the risk of bias assessment. Meta-analysis was conducted using a random effects model.Results Twelve studies satisfied the eligibility criteria. Previous history of an ACL injury was associated with an increased risk of subsequent hamstring injury (three studies, RR=2.25, 95\% CI 1.34 to 3.76), but a history of chronic groin injury was not associated with subsequent hamstring injury (three studies, RR=1.14, 95\% CI 0.29 to 4.51). Previous lower limb muscular injury was associated with an increased risk of sustaining a lower limb muscular injury at a different site. A history of concussion and a variety of joint injuries were associated with an increased subsequent lower limb injury risk.Conclusions The fact that previous injury of any type may increase the risk for a range of lower limb subsequent injuries must be considered in the development of future tertiary prevention programmes.Systematic review registration number CRD42016039904 (PROSPERO).}, issn = {0306-3674}, URL = {https://bjsm.bmj.com/content/51/23/1670}, eprint = {https://bjsm.bmj.com/content/51/23/1670.full.pdf}, journal = {British Journal of Sports Medicine} }