RT Journal Article
SR Electronic
T1 Does physical activity increase or decrease the risk of sickle cell disease complications?
JF British Journal of Sports Medicine
JO Br J Sports Med
FD BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine
SP 214
OP 218
DO 10.1136/bjsports-2015-095317
VO 52
IS 4
A1 Martin, Cyril
A1 Pialoux, Vincent
A1 Faes, Camille
A1 Charrin, Emmanuelle
A1 Skinner, Sarah
A1 Connes, Philippe
YR 2018
UL http://bjsm.bmj.com/content/52/4/214.abstract
AB Sickle cell disease (SCD) is the most common inherited disease in the world. Red blood cell sickling, blood cell-endothelium adhesion, blood rheology abnormalities, intravascular haemolysis, and increased oxidative stress and inflammation contribute to the pathophysiology of SCD. Because acute intense exercise may alter these pathophysiological mechanisms, physical activity is usually contra-indicated in patients with SCD. However, recent studies in sickle-cell trait carriers and in a SCD mice model show that regular physical activity could decrease oxidative stress and inflammation, limit blood rheology alterations and increase nitric oxide metabolism. Therefore, supervised habitual physical activity may benefit patients with SCD. This article reviews the literature on the effects of acute and chronic exercise on the biological responses and clinical outcomes of patients with SCD.