TY - JOUR T1 - Exercise does not ‘wear down my knee’: systematic reviews and meta-analyses JF - British Journal of Sports Medicine JO - Br J Sports Med SP - 1591 LP - 1592 DO - 10.1136/bjsports-2018-099705 VL - 52 IS - 24 AU - Alessio Bricca Y1 - 2018/12/01 UR - http://bjsm.bmj.com/content/52/24/1591.abstract N2 - I investigated the impact of exercise on knee joint articular cartilage. This aim was investigated in three different systematic reviews (SRs) of randomised controlled trials (RCTs) in healthy animals and in humans at risk of or with knee osteoarthritis (OA).Exercise is the first-line treatment for knee OA.1 Yet, many people still believe that exercise may ‘wear down my knee’ creating a barrier to exercise.Articular cartilage is the hallmark of OA and the structure I studied in my PhD. It is a connective tissue that covers bone ends in the joints and provides lubrication of the meeting surfaces, allowing the transmission of loads with a low frictional coefficient. Aggrecan, collagen and molecular biomarkers are the molecules responsible for maintaining cartilage integrity, function and metabolism, and … ER -