RT Journal Article SR Electronic T1 How does occupational physical activity influence health? An umbrella review of 23 health outcomes across 158 observational studies JF British Journal of Sports Medicine JO Br J Sports Med FD BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine SP 1474 OP 1481 DO 10.1136/bjsports-2020-102587 VO 54 IS 24 A1 Bart Cillekens A1 Matthias Lang A1 Willem van Mechelen A1 Evert Verhagen A1 Maaike A Huysmans A1 Andreas Holtermann A1 Allard J van der Beek A1 Pieter Coenen YR 2020 UL http://bjsm.bmj.com/content/54/24/1474.abstract AB Objective Physical activity (PA) has substantial benefits across a range of health outcomes. There is uncertainty about the PA-specific health effects, and in particular, the occupational domain. In this umbrella review, we synthesised available evidence on the associations between occupational PA (OPA) and health-related outcomes (including cancer, all-cause mortality and cardiovascular disease). This work informed the development of WHO’s guidelines on PA and sedentary behaviour (2020).Design Umbrella review of systematic reviews.Data source We performed a literature search in PubMed, Web of Science, Embase, CINAHL and Sportdiscuss from database inception to 2 December 2019.Eligibility criteria for selecting studies We included systematic reviews if they contained a quantitative assessment of OPA and its relationship with at least one health-related outcome.Results We summarised the evidence of 17 reviews covering 23 unique health-related outcomes. We graded most evidence as low or very low, or moderate quality. We found health benefits for those engaging in high versus low OPA for multiple cancer outcomes (including colon and prostate), ischaemic stroke, coronary heart disease and mental health (ie, mental well-being and life satisfaction). High OPA was associated with unfavourable health outcomes for all-cause mortality in men, mental ill health (ie, depression and anxiety), osteoarthritis, and sleep quality and duration.Conclusions We found favourable associations for most health-related outcomes with high OPA levels, but we also found some evidence for unfavourable associations due to high OPA levels. At this point, there is a need for better quality evidence to provide a unequivocal statement on the health effects of OPA.