RT Journal Article SR Electronic T1 A novel approach to improve detection of glucocorticoid doping in sport with new guidance for physicians prescribing for athletes JF British Journal of Sports Medicine JO Br J Sports Med FD BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine SP 631 OP 642 DO 10.1136/bjsports-2020-103512 VO 55 IS 11 A1 Rosa Ventura A1 Peter Daley-Yates A1 Irene Mazzoni A1 Katia Collomp A1 Martial Saugy A1 Frank Buttgereit A1 Olivier Rabin A1 Mark Stuart YR 2021 UL http://bjsm.bmj.com/content/55/11/631.abstract AB The systemic effect of glucocorticoids (GCs) following injectable routes of administration presents a potential risk to both improving performance and causing harm to health in athletes. This review evaluates the current GC antidoping regulations defined by the World Anti-Doping Agency and presents a novel approach for defining permitted and prohibited use of glucocorticoids in sport based on the pharmacological potential for performance enhancement (PE) and risk of adverse effects on health. Known performance-enhancing doses of glucocorticoids are expressed in terms of cortisol-equivalent doses and thereby the dose associated with a high potential for PE for any GC and route of administration can be derived. Consequently, revised and substance-specific laboratory reporting values are presented to better distinguish between prohibited and permitted use in sport. In addition, washout periods are presented to enable clinicians to prescribe glucocorticoids safely and to avoid the risk of athletes testing positive for a doping test.