TY - JOUR T1 - Joint association between accelerometry-measured daily combination of time spent in physical activity, sedentary behaviour and sleep and all-cause mortality: a pooled analysis of six prospective cohorts using compositional analysis JF - British Journal of Sports Medicine JO - Br J Sports Med SP - 1277 LP - 1285 DO - 10.1136/bjsports-2020-102345 VL - 55 IS - 22 AU - Sebastien Chastin AU - Duncan McGregor AU - Javier Palarea-Albaladejo AU - Keith M Diaz AU - Maria Hagströmer AU - Pedro Curi Hallal AU - Vincent T van Hees AU - Steven Hooker AU - Virginia J Howard AU - I-Min Lee AU - Philip von Rosen AU - Séverine Sabia AU - Eric J Shiroma AU - Manasa S Yerramalla AU - Philippa Dall Y1 - 2021/11/01 UR - http://bjsm.bmj.com/content/55/22/1277.abstract N2 - Objective To examine the joint associations of daily time spent in different intensities of physical activity, sedentary behaviour and sleep with all-cause mortality.Methods Federated pooled analysis of six prospective cohorts with device-measured time spent in different intensities of physical activity, sedentary behaviour and sleep following a standardised compositional Cox regression analysis.Participants 130 239 people from general population samples of adults (average age 54 years) from the UK, USA and Sweden.Main outcome All-cause mortality (follow-up 4.3–14.5 years).Results Studies using wrist and hip accelerometer provided statistically different results (I2=92.2%, Q-test p<0.001). There was no association between duration of sleep and all-cause mortality, HR=0.96 (95% CI 0.67 to 1.12). The proportion of time spent in moderate to vigorous physical activity was significantly associated with lower risk of all-cause mortality (HR=0.63 (95% CI 0.55 to 0.71) wrist; HR=0.93 (95% CI 0.87 to 0.98) hip). A significant association for the ratio of time spent in light physical activity and sedentary time was only found in hip accelerometer-based studies (HR=0.5, 95% CI 0.42 to 0.62). In studies based on hip accelerometer, the association between moderate to vigorous physical activity and mortality was modified by the balance of time spent in light physical activity and sedentary time.Conclusion This federated analysis shows a joint dose–response association between the daily balance of time spent in physical activity of different intensities and sedentary behaviour with all-cause mortality, while sleep duration does not appear to be significant. The strongest association is with time spent in moderate to vigorous physical activity, but it is modified by the balance of time spent in light physical activity relative to sedentary behaviour.Data are available in a public, open-access repository. Data may be obtained from a third party and are not publicly available. Some of the data sets included in this study are open access and others are curated by the studies. This is detailed in the manuscript and supplemental material. ER -