TY - JOUR T1 - Highlights from the American Medical Society for Sports Medicine position statement on responsible use of regenerative medicine and orthobiologics in sports medicine JF - British Journal of Sports Medicine JO - Br J Sports Med SP - 121 LP - 122 DO - 10.1136/bjsports-2021-104887 VL - 56 IS - 3 AU - Shane A Shapiro AU - Jonathan T Finnoff AU - Tariq M Awan AU - Joanne P Borg-Stein AU - Kimberly G Harmon AU - Daniel C Herman AU - Gerard Malanga AU - Zubin Master AU - Kenneth Mautner Y1 - 2022/02/01 UR - http://bjsm.bmj.com/content/56/3/121.abstract N2 - Musculoskeletal conditions including osteoarthritis and chronic tendinopathies are leading causes of pain and disability worldwide. The emergence of novel regenerative therapies, referred to as orthobiologics, has led to promising interventions which may reduce pain and improve function. Orthobiologics are biological substances intended to enhance healing and alter the natural course of orthopaedic disease.1 2 Despite growing experience, the field remains under-researched with inconsistent evidence; yet increasing enthusiasm has permitted overexuberant, sometimes inappropriate use with proliferation of misinformation among both providers and patients.An American Medical Society for Sports Medicine (AMSSM) position statement was developed to help sports medicine physicians make informed and responsible decisions about the role of regenerative medicine in their practice.3 The statement contains relevant terminology, review of basic and clinical science, ethics, regulations and best practices for considering regenerative medicine in clinical practice (figure 1). The statement seeks to educate physicians regarding a broad and emerging discipline and is not an endorsement by AMSSM of any specific product or procedure.Figure 1 Responsible use of orthobiologics and other novel regenerative therapies requires multiple considerations before translation into routine clinical practice.Regenerative medicine is rapidly growing with terms and definitions yet to be standardised. While originating with stem cell discovery and translation, regenerative therapies, of which orthobiologics is but one category, are no longer a single platform technology. Rather, they now encompass a heterogeneous collection of biological sources with varying activity that hold the potential to transform human health. Common orthobiologics employed in research and clinical practice are being conflated under the umbrella of ‘stem cell’ therapy in a … ER -