@article {Wood1032, author = {Gina Wood and Emily Taylor and Vanessa Ng and Anna Murrell and Aditya Patil and Tom van der Touw and Ronald Sigal and Mitch Wolden and Neil Smart}, title = {Determining the effect size of aerobic exercise training on the standard lipid profile in sedentary adults with three or more metabolic syndrome factors: a systematic review and meta-analysis of randomised controlled trials}, volume = {56}, number = {18}, pages = {1032--1041}, year = {2022}, doi = {10.1136/bjsports-2021-103999}, publisher = {British Association of Sport and Excercise Medicine}, abstract = {Objectives To estimate the change in the standard lipid profile (SLP) of adults diagnosed with >=3 metabolic syndrome (MetS) factors following aerobic exercise training (AET); and to investigate whether study/intervention covariates are associated with this change.Design Systematic review with univariate meta-analysis and meta-regression.Data sources English language searches of online databases from inception until July 2020.Eligibility criteria (1) Published randomised controlled human trials with study population >=10 per group; (2) sedentary adults with >=3 MetS factors but otherwise free of chronic disease, not pregnant/lactating; (3) AET-only intervention with duration >=12 weeks; and (4) reporting pre{\textendash}post intervention SLP outcomes.Results Various univariate meta-analyses pooled 48 data sets of 2990 participants. Aerobic exercise training significantly (P\<.001) improved all lipids (mmol/L mean difference ranges, 95\% CIs): total cholesterol, {\textendash}0.19 ({\textendash}0.26 to {\textendash}0.12) to {\textendash}0.29 (-0.36 to {\textendash}0.21); triglycerides, -0.17 ({\textendash}0.19 to {\textendash}0.14) to {\textendash}0.18 (-0.24 to {\textendash}0.13); high-density lipoprotein-cholesterol (HDL-C), 0.05 (0.03 to 0.07) to 0.10 (0.05 to 0.15); and low-density lipoprotein-cholesterol (LDL-C), {\textendash}0.12 ({\textendash}0.16 to {\textendash}0.9) to {\textendash}0.20 (-0.25 to {\textendash}0.14). Meta-regression showed that intensity may explain change in triglycerides and volume may explain change in HDL-C and LDL-C.Conclusion Aerobic exercise training positively changes the SLP of sedentary and otherwise healthy adults with >=3 MetS factors. Adjusting AET intervention training variables may increase the effects of AET on triglycerides and HDL-C.PROSPERO registration number CRD42020151925.}, issn = {0306-3674}, URL = {https://bjsm.bmj.com/content/56/18/1032}, eprint = {https://bjsm.bmj.com/content/56/18/1032.full.pdf}, journal = {British Journal of Sports Medicine} }