PT  - JOURNAL ARTICLE
AU  - Gina Wood
AU  - Emily Taylor
AU  - Vanessa Ng
AU  - Anna Murrell
AU  - Aditya Patil
AU  - Tom van der Touw
AU  - Ronald Sigal
AU  - Mitch Wolden
AU  - Neil Smart
TI  - Determining the effect size of aerobic exercise training on the standard lipid profile in sedentary adults with three or more metabolic syndrome factors: a systematic review and meta-analysis of randomised controlled trials
AID  - 10.1136/bjsports-2021-103999
DP  - 2022 Sep 01
TA  - British Journal of Sports Medicine
PG  - 1032--1041
VI  - 56
IP  - 18
4099  - http://bjsm.bmj.com/content/56/18/1032.short
4100  - http://bjsm.bmj.com/content/56/18/1032.full
SO  - Br J Sports Med2022 Sep 01; 56
AB  - Objectives To estimate the change in the standard lipid profile (SLP) of adults diagnosed with ≥3 metabolic syndrome (MetS) factors following aerobic exercise training (AET); and to investigate whether study/intervention covariates are associated with this change.Design Systematic review with univariate meta-analysis and meta-regression.Data sources English language searches of online databases from inception until July 2020.Eligibility criteria (1) Published randomised controlled human trials with study population ≥10 per group; (2) sedentary adults with ≥3 MetS factors but otherwise free of chronic disease, not pregnant/lactating; (3) AET-only intervention with duration ≥12 weeks; and (4) reporting pre–post intervention SLP outcomes.Results Various univariate meta-analyses pooled 48 data sets of 2990 participants. Aerobic exercise training significantly (P<.001) improved all lipids (mmol/L mean difference ranges, 95% CIs): total cholesterol, –0.19 (–0.26 to –0.12) to –0.29 (−0.36 to –0.21); triglycerides, −0.17 (–0.19 to –0.14) to –0.18 (−0.24 to –0.13); high-density lipoprotein-cholesterol (HDL-C), 0.05 (0.03 to 0.07) to 0.10 (0.05 to 0.15); and low-density lipoprotein-cholesterol (LDL-C), –0.12 (–0.16 to –0.9) to –0.20 (−0.25 to –0.14). Meta-regression showed that intensity may explain change in triglycerides and volume may explain change in HDL-C and LDL-C.Conclusion Aerobic exercise training positively changes the SLP of sedentary and otherwise healthy adults with ≥3 MetS factors. Adjusting AET intervention training variables may increase the effects of AET on triglycerides and HDL-C.PROSPERO registration number CRD42020151925.