RT Journal Article SR Electronic T1 Transform-Us! cluster RCT: 18-month and 30-month effects on children’s physical activity, sedentary time and cardiometabolic risk markers JF British Journal of Sports Medicine JO Br J Sports Med FD BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine SP 311 OP 319 DO 10.1136/bjsports-2022-105825 VO 57 IS 5 A1 Jo Salmon A1 Lauren Arundell A1 Ester Cerin A1 Nicola Dawn Ridgers A1 Kylie D Hesketh A1 Robin M Daly A1 David Dunstan A1 Helen Brown A1 Jacqui Della Gatta A1 Paul Della Gatta A1 Mai J M Chinapaw A1 Lauren Shepphard A1 Marj Moodie A1 Clare Hume A1 Vicki Brown A1 Kylie Ball A1 David Crawford YR 2023 UL http://bjsm.bmj.com/content/57/5/311.abstract AB Objective To test the efficacy of the Transform-Us! school- and home-based intervention on children’s physical activity (PA), sedentary behaviour (SB) and cardiometabolic risk factor profiles.Methods A 30-month 2×2 factorial design cluster randomised controlled trial delivered in 20 primary schools (148 Year 3 classes) in Melbourne, Australia (2010–2012), that used pedagogical and environmental strategies to reduce and break up SB, promote PA or a combined approach, compared with usual practice. Primary outcomes (accelerometry data; n=348) were assessed at baseline, 18 and 30 months. Secondary outcomes included body mass index (BMI) and waist circumference (WC) (n=564), blood pressure (BP) (n=537) and biomarkers (minimum n=206). Generalised linear mixed models estimated the interactive effects of the PA and SB interventions on the outcomes. If there was no interaction, the main effects were assessed.Results At 18 months, there were intervention effects on children’s weekday SB (−27 min, 95% CI: −47.3 to −5.3) for the PA intervention, and on children’s average day PA (5.5 min, 95% CI: 0.1 to 10.8) for the SB intervention. At 30 months, there was an intervention effect for children’s average day SB (−33.3 min, 95% CI: −50.6 and −16.0) for the SB intervention. Children’s BMI (PA and SB groups) and systolic BP (combined group) were lower, and diastolic BP (PA group) was higher. There were positive effects on WC at both time points (SB intervention) and mixed effects on blood parameters.Conclusions The Transform-Us! PA and SB interventions show promise as a pragmatic approach for reducing children’s SB and adiposity indicators; but achieving substantial increases in PA remains challenging.Trial registration ISRCTN83725066; ACTRN12609000715279.Data are available upon reasonable request.