PT - JOURNAL ARTICLE AU - Iverson, Grant L AU - Castellani, Rudolph J AU - Cassidy, J David AU - Schneider, Geoff M AU - Schneider, Kathryn J AU - Echemendia, Ruben J AU - Bailes, Julian E AU - Hayden, K Alix AU - Koerte, Inga K AU - Manley, Geoffrey T AU - McNamee, Michael AU - Patricios, Jon S AU - Tator, Charles H AU - Cantu, Robert C AU - Dvorak, Jiri TI - Examining later-in-life health risks associated with sport-related concussion and repetitive head impacts: a systematic review of case-control and cohort studies AID - 10.1136/bjsports-2023-106890 DP - 2023 Jun 01 TA - British Journal of Sports Medicine PG - 810--824 VI - 57 IP - 12 4099 - http://bjsm.bmj.com/content/57/12/810.short 4100 - http://bjsm.bmj.com/content/57/12/810.full SO - Br J Sports Med2023 Jun 01; 57 AB - Objective Concern exists about possible problems with later-in-life brain health, such as cognitive impairment, mental health problems and neurological diseases, in former athletes. We examined the future risk for adverse health effects associated with sport-related concussion, or exposure to repetitive head impacts, in former athletes.Design Systematic review.Data sources Search of MEDLINE, Embase, Cochrane, CINAHL Plus and SPORTDiscus in October 2019 and updated in March 2022.Eligibility criteria Studies measuring future risk (cohort studies) or approximating that risk (case-control studies).Results Ten studies of former amateur athletes and 18 studies of former professional athletes were included. No postmortem neuropathology studies or neuroimaging studies met criteria for inclusion. Depression was examined in five studies in former amateur athletes, none identifying an increased risk. Nine studies examined suicidality or suicide as a manner of death, and none found an association with increased risk. Some studies comparing professional athletes with the general population reported associations between sports participation and dementia or amyotrophic lateral sclerosis (ALS) as a cause of death. Most did not control for potential confounding factors (eg, genetic, demographic, health-related or environmental), were ecological in design and had high risk of bias.Conclusion Evidence does not support an increased risk of mental health or neurological diseases in former amateur athletes with exposure to repetitive head impacts. Some studies in former professional athletes suggest an increased risk of neurological disorders such as ALS and dementia; these findings need to be confirmed in higher quality studies with better control of confounding factors.PROSPERO registration number CRD42022159486.All data relevant to the study are included in the article or uploaded as supplementary information.