RT Journal Article
SR Electronic
T1 Association of accelerometer-measured physical activity and its change with progression to chronic kidney disease in adults with type 2 diabetes and overweight/obesity
JF British Journal of Sports Medicine
JO Br J Sports Med
FD BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine
SP 313
OP 319
DO 10.1136/bjsports-2023-107564
VO 58
IS 6
A1 Liu, Mengyi
A1 Zhang, Yanjun
A1 Zhang, Yuanyuan
A1 He, Panpan
A1 Zhou, Chun
A1 Ye, Ziliang
A1 Yang, Sisi
A1 Gan, Xiaoqin
A1 Hou, Fan Fan
A1 Qin, Xianhui
YR 2024
UL http://bjsm.bmj.com/content/58/6/313.abstract
AB Objective To examine the long-term association of objectively measured moderate-to-vigorous physical activity (MVPA) and its longitudinal changes with progression to chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) and overweight/obesity.Methods This study included 1746 participants in the Look AHEAD trial with baseline estimated glomerular filtration rate (eGFR)≥60 mL/min/1.73 m2. MVPA was measured at baseline, year 1, year 4 and year 8 using an RT3 accelerometer. The outcome was progression to CKD, defined as eGFR<60 mL/min per 1.73 m2 with a drop of ≥30% or end-stage kidney disease. Cox hazards models were fitted to examine the association between MVPA and outcomes.Results Over a median follow-up of 12.0 years, 567 participants experienced progression to CKD. Overall, there was a linear inverse association of cumulative average total MVPA (per 100 min/week higher amount, HR: 0.91; 95% CI: 0.86 to 0.96) and MVPA accumulated in bouts of ≥10 min (per 100 minutes/week higher amount, HR: 0.81; 95% CI: 0.72 to 0.91) with progression to CKD. Moreover, an increase in total MVPA from baseline to year 4 (the fourth quartile, ≥63.2 min/week) was associated with a 33% lower risk of progression to CKD compared with the largest MVPA reduction (the first quartile, <−198.3 min/week). A lower risk of progression to CKD was also observed for increases in MVPA accumulated in bouts of both <10 min and ≥10 min.Conclusions Longer MVPA time and increases in MVPA was associated with a reduced risk of progression to CKD in adults with overweight/obesity and T2D.Data may be obtained from a third party and are not publicly available. The data sets analysed in the current study are available on application at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Repository.