PT  - JOURNAL ARTICLE
AU  - Evans, J. A.
AU  - Lambert, M. B.
AU  - Miller, J.
TI  - The excretion of ibuprofen by the horse - a preliminary report.
AID  - 10.1136/bjsm.10.3.124
DP  - 1976 Oct 01
TA  - British Journal of Sports Medicine
PG  - 124--127
VI  - 10
IP  - 3
4099  - http://bjsm.bmj.com/content/10/3/124.short
4100  - http://bjsm.bmj.com/content/10/3/124.full
SO  - Br J Sports Med1976 Oct 01; 10
AB  - The anti-inflammatory drug Ibuprofen [(+/-)-2-(p-isobutylphenyl) propionic acid] was estimated in the blood and urine of a horse using gas-liquid chromatography of the silylated derivative. Levels of the drug in the two body fluids were measured over a period of about 24 hours after administering a 12 gm dose of Ibuprofen. Plasma peak levels were observed within 30 to 60 min, and the drug was no longer detectable in the plasma by 8 hr. Urinary peak levels were observed 200 to 300 min after dosing, and the drug was no longer detectable in the urine by about 28 hr. It was observed that only 2% to 6% of the free unchanged drug was excreted in the urine.