RT Journal Article
SR Electronic
T1 The excretion of ibuprofen by the horse - a preliminary report.
JF British Journal of Sports Medicine
JO Br J Sports Med
FD BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine
SP 124
OP 127
DO 10.1136/bjsm.10.3.124
VO 10
IS 3
A1 Evans, J. A.
A1 Lambert, M. B.
A1 Miller, J.
YR 1976
UL http://bjsm.bmj.com/content/10/3/124.abstract
AB The anti-inflammatory drug Ibuprofen [(+/-)-2-(p-isobutylphenyl) propionic acid] was estimated in the blood and urine of a horse using gas-liquid chromatography of the silylated derivative. Levels of the drug in the two body fluids were measured over a period of about 24 hours after administering a 12 gm dose of Ibuprofen. Plasma peak levels were observed within 30 to 60 min, and the drug was no longer detectable in the plasma by 8 hr. Urinary peak levels were observed 200 to 300 min after dosing, and the drug was no longer detectable in the urine by about 28 hr. It was observed that only 2% to 6% of the free unchanged drug was excreted in the urine.