PT - JOURNAL ARTICLE AU - Lambert, E V AU - St Clair Gibson, A AU - Noakes, T D TI - Complex systems model of fatigue: integrative homoeostatic control of peripheral physiological systems during exercise in humans AID - 10.1136/bjsm.2003.011247 DP - 2005 Jan 01 TA - British Journal of Sports Medicine PG - 52--62 VI - 39 IP - 1 4099 - http://bjsm.bmj.com/content/39/1/52.short 4100 - http://bjsm.bmj.com/content/39/1/52.full SO - Br J Sports Med2005 Jan 01; 39 AB - Fatigue is hypothesised as being the result of the complex interaction of multiple peripheral physiological systems and the brain. In this new model, all changes in peripheral physiological systems such as substrate depletion or metabolite accumulation act as afferent signallers which modulate control processes in the brain in a dynamic, non-linear, integrative manner.