RT Journal Article SR Electronic T1 Complex systems model of fatigue: integrative homoeostatic control of peripheral physiological systems during exercise in humans JF British Journal of Sports Medicine JO Br J Sports Med FD BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine SP 52 OP 62 DO 10.1136/bjsm.2003.011247 VO 39 IS 1 A1 Lambert, E V A1 St Clair Gibson, A A1 Noakes, T D YR 2005 UL http://bjsm.bmj.com/content/39/1/52.abstract AB Fatigue is hypothesised as being the result of the complex interaction of multiple peripheral physiological systems and the brain. In this new model, all changes in peripheral physiological systems such as substrate depletion or metabolite accumulation act as afferent signallers which modulate control processes in the brain in a dynamic, non-linear, integrative manner.