PT - JOURNAL ARTICLE AU - Hodges, A N H AU - Lynn, B M AU - Koehle, M S AU - McKenzie, D C TI - Effects of inhaled bronchodilators and corticosteroids on exercise induced arterial hypoxaemia in trained male athletes AID - 10.1136/bjsm.2005.017806 DP - 2005 Dec 01 TA - British Journal of Sports Medicine PG - 917--920 VI - 39 IP - 12 4099 - http://bjsm.bmj.com/content/39/12/917.short 4100 - http://bjsm.bmj.com/content/39/12/917.full SO - Br J Sports Med2005 Dec 01; 39 AB - Objectives: To determine the effect of prophylactic treatment with an inhaled bronchodilator and anti-inflammatory on arterial saturation (Sao2) in trained non-asthmatic male athletes with exercise induced arterial hypoxaemia (EIAH). Methods: Nine male athletes (mean (SD) age 26.3 (6.7) years, height 182.6 (7.9) cm, weight 79.3 (10.5) kg, Vo2max 62.3 (6.3) ml/kg/min, Sao2min 92.5 (1.1)%) with no history of asthma were tested in two experimental conditions. A combination of a therapeutic dose of salbutamol and fluticasone or an inert placebo was administered in a randomised crossover design for seven days before maximal cycling exercise. Oxygen consumption (Vo2), ventilation (Ve), heart rate (HR), power output, and Sao2 were monitored during the exercise tests. Results: There were no significant differences between the drug (D) and placebo (P) conditions for minimal Sao2 (D  =  93.6 (1.4), P  =  93.0 (1.1)%; p  =  0.93) Vo2max (D  =  61.5 (7.2), P  =  61.9 (6.3) ml/kg/min; p  =  0.91), peak power (D  =  444.4 (48.3), P  =  449.4 (43.9) W; p  =  0.90), peak Ve (D  =  147.8 (19.1), P  =  149.2 (15.5) litres/min; p  =  0.82), or peak heart rate (D  =  182.3 (10.0), P  =  180.8 (5.5) beats/min; p  =  0.76). Conclusions: A therapeutic dose of salbutamol and fluticasone did not attenuate EIAH during maximal cycling in a group of trained male non-asthmatic athletes.