TY - JOUR T1 - Does complete deficiency of muscle α actinin 3 alter functional capacity in elderly women? A preliminary report JF - British Journal of Sports Medicine JO - Br J Sports Med SP - e1 LP - e1 DO - 10.1136/bjsm.2005.019539 VL - 40 IS - 1 AU - A F San Juan AU - F Gomez-Gallego AU - S Cañete AU - C Santiago AU - M Pérez AU - A Lucia Y1 - 2006/01/01 UR - http://bjsm.bmj.com/content/40/1/e1.abstract N2 - The sarcomeric protein α actinin 3 is localised to the Z line of fast fibres, which are responsible for generating forceful muscle contractions at high velocity. However, a substantial proportion of healthy humans are totally deficient in this protein as they are homozygous for a premature stop codon polymorphism (R577X) in the ACTN3 gene. The purpose of this preliminary study was to assess if the presence or absence of α actinin 3 influences the deleterious effects of ageing on muscle output and functional capacity. ER -