PT - JOURNAL ARTICLE AU - D Q Zhou AU - Y Hu AU - G Liu AU - L Gong AU - Y Xi AU - L Wen TI - Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme AID - 10.1136/bjsm.2006.029744 DP - 2006 Dec 01 TA - British Journal of Sports Medicine PG - 988--991 VI - 40 IP - 12 4099 - http://bjsm.bmj.com/content/40/12/988.short 4100 - http://bjsm.bmj.com/content/40/12/988.full SO - Br J Sports Med2006 Dec 01; 40 AB - Objective: To investigate the association between muscle-specific creatine kinase (CKMM) gene polymorphism and the effects of endurance training on running economy. Methods: 102 biologically unrelated male volunteers from northern China performed a 5000-m running programme, with an intensity of 95–105% ventilatory threshold. The protocol was undertaken three times per week and lasted for 18 weeks. Running economy indexes were determined by making the participants run on a treadmill before and after the protocol, and the A/G polymorphism in the 3′ untranslated region of CKMM was detected by polymerase chain reaction-restricted fragment length polymorphism (NcoI restriction enzyme). Results: Three expected genotypes for CKMM-NcoI (AA, AG and GG) were observed in the participants. After training, all running economy indexes declined markedly. Change in steady-state consumption of oxygen, change in steady-state consumption of oxygen by mean body weight, change in steady-state consumption of oxygen by mean lean body weight and change in ventilatory volume in AG groups were larger than those in AA and GG groups. Conclusions: The findings indicate that the CKMM gene polymorphism may contribute to individual running economy responses to endurance training.