PT  - JOURNAL ARTICLE
AU  - K Knubben
AU  - F M Reischies
AU  - M Adli
AU  - P Schlattmann
AU  - M Bauer
AU  - F Dimeo
TI  - A randomised, controlled study on the effects of a short-term endurance training programme in patients with major depression
AID  - 10.1136/bjsm.2006.030130
DP  - 2007 Jan 01
TA  - British Journal of Sports Medicine
PG  - 29--33
VI  - 41
IP  - 1
4099  - http://bjsm.bmj.com/content/41/1/29.short
4100  - http://bjsm.bmj.com/content/41/1/29.full
SO  - Br J Sports Med2007 Jan 01; 41
AB  - Objective: To evaluate the short-term effects of exercise in patients with major depression. Design: Prospective, randomised, controlled study. Setting: A university hospital. Patients: A consecutive series of 38 inpatients with a major depression episode undergoing standard clinical antidepressant drug treatment. Interventions: Patients were randomly assigned to an exercise (walking, n = 20) or placebo (low-intensity stretching and relaxation exercises, n = 18) group. Training was carried out for 10 days. Main outcome measurements: Severity of depression assessed with the Bech-Rafaelsen Melancholy Scale (BRMS) and the Center for Epidemiologic Studies Depression scale (CES-D). Results: After 10 days, reduction of depression scores in the exercise group was significantly larger than in the placebo group (BRMS: 36% v 18%; CES-D: 41% v 21%; p for both  = 0.01); the proportion of patients with a clinical response (reduction in the BRMS scores by more than six points) was also larger for the exercise group (65% v 22%, p<0.01). Conclusions: Endurance exercise may help to achieve substantial improvement in the mood of selected patients with major depression in a short time.